Evidence map›Paper›PMID 32559588›Full record

ArticleDiagnostic microbiology and infectious disease2020

Impact of FilmArray meningitis encephalitis panel on HSV testing and empiric acyclovir use in children beyond the neonatal period.

Kevin Messacar, James T Gaensbauer, Meghan Birkholz, Claire Palmer, James K Todd, Kenneth L Tyler, Samuel R Dominguez

Open access · greenAbstract read
In one paragraph

Article in Diagnostic microbiology and infectious disease, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
2.0field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 20 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Kevin MessacarUniversity of Colorado School of Medicine Aurora, CO USA; Children's Hospital Colorado Aurora, CO USA. Electronic address: kevin.messacar@childrenscolorado.org.
James T GaensbauerUniversity of Colorado School of Medicine Aurora, CO USA; Children's Hospital Colorado Aurora, CO USA.
Meghan BirkholzChildren's Hospital Colorado Aurora, CO USA.
Claire PalmerUniversity of Colorado School of Medicine Aurora, CO USA.
James K ToddUniversity of Colorado School of Medicine Aurora, CO USA; Children's Hospital Colorado Aurora, CO USA.
Kenneth L TylerUniversity of Colorado School of Medicine Aurora, CO USA.
Samuel R DominguezUniversity of Colorado School of Medicine Aurora, CO USA; Children's Hospital Colorado Aurora, CO USA.
University of Colorado Denver · USChildren's Hospital Colorado · US

Funding

Implementation and Effectiveness of a Rapid Cerebrospinal Fluid Diagnostics Program for Children with Suspected Central Nervous System InfectionK23AI128069 · NIAID · UNIVERSITY OF COLORADO DENVER · PI MESSACAR, KEVIN BRETT · 2017 to 2021
$878k
NIAID NIH HHS K23 AI128069
6 · The paper itself

Abstract

Following implementation of the FilmArray meningitis and encephalitis panel, which enables rapid syndromic cerebrospinal fluid testing, HSV testing doubled in children >60 days with suspected central nervous system infection at Children's Hospital Colorado. Acyclovir initiation was unchanged, but duration decreased. Diagnostic and antimicrobial stewardship is needed for MEP optimization.

Indexed as

AcyclovirAdolescentAntimicrobial StewardshipAntiviral AgentsCentral Nervous System InfectionsChildChild, PreschoolEncephalitis, Herpes SimplexFemaleHospitals, PediatricHumansInfantMaleMeningitis, ViralMolecular Diagnostic TechniquesMultiplex Polymerase Chain ReactionAcyclovirAntiviral AgentsAcyclovirAntimicrobial stewardshipDiagnosticsDiagnostic stewardshipEncephalitisHerpesMeningitisPediatrics

Identifiers

PMID32559588
PMCPMC7384938
OpenAlexW3024334675

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.