Evidence map›Paper›PMID 32559382›Full record

ArticleThe Journal of organic chemistry2020

Next-Generation TLC: A Quantitative Platform for Parallel Spotting and Imaging.

Alexander A Boulgakov, Sarah R Moor, Hyun Hwa Jo, Pedro Metola, Leo A Joyce, Edward M Marcotte, Christopher J Welch, Eric V Anslyn

Open access · greenAbstract read
In one paragraph

Article in The Journal of organic chemistry, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.8field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 16 citations in OpenAlex.

  1. Article
  2. Article
  3. Parallel and High Throughput Reaction Monitoring with Computer Vision.Angewandte Chemie (International ed. in English) · 2025
    Article
  4. Article
  5. Article
  6. Review
  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Alexander A BoulgakovCenter for Systems and Synthetic Biology/Institute for Cellular and Molecular Biology, Department of Molecular Biosciences, The University of Texas at Austin, Austin, Texas 78712, United States.
Sarah R MoorDepartment of Chemistry, The University of Texas at Austin, Austin, Texas 78712, United States.ORCID 0000-0001-5579-407X
Hyun Hwa JoDepartment of Chemistry, The University of Texas at Austin, Austin, Texas 78712, United States.
Pedro MetolaDepartment of Chemistry, The University of Texas at Austin, Austin, Texas 78712, United States.
Leo A JoyceDepartment of Process Research and Development, Merck & Co., Inc., Rahway, New Jersey 07065, United States.ORCID 0000-0002-8649-4894
Edward M MarcotteCenter for Systems and Synthetic Biology/Institute for Cellular and Molecular Biology, Department of Molecular Biosciences, The University of Texas at Austin, Austin, Texas 78712, United States.
Christopher J WelchDepartment of Process Research and Development, Merck & Co., Inc., Rahway, New Jersey 07065, United States.ORCID 0000-0002-8899-4470
Eric V AnslynCenter for Systems and Synthetic Biology/Institute for Cellular and Molecular Biology, Department of Molecular Biosciences, The University of Texas at Austin, Austin, Texas 78712, United States.
The University of Texas at Austin · USMerck & Co., Inc., Rahway, NJ, USA (United States) · US

Funding

Bruker AVANCE III HD 500 MHz NMRS10OD021508 · OD · UNIVERSITY OF TEXAS AT AUSTIN · PI SESSLER, JONATHAN L · 2016 to 2016
$529k
Howard Hughes Medical Institute GT10481NIH HHS S10 OD021508
6 · The paper itself

Abstract

A high-throughput screening approach for simultaneous analysis and quantification of the percent conversion of up to 48 reactions has been developed using a thin-layer chromatography (TLC) imaging method. As a test-bed reaction, we monitored 48 thiol conjugate additions to a Meldrum's acid derivative (

Indexed as

Ultraviolet RaysChromatography, Thin Layer

Identifiers

PMID32559382
PMCPMC7748073
OpenAlexW3036945895

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.