Evidence map›Paper›PMID 32559373›Full record

ArticleBiochemistry2020

Allosteric Influence of Extremophile Hairpin Motif Mutations on the Protein Splicing Activity of a Hyperthermophilic Intein.

Kathryn C Chiarolanzio, Jennifer M Pusztay, Angel Chavez, Jing Zhao, Jian Xie, Chunyu Wang, Kenneth V Mills

Open access · greenAbstract read
In one paragraph

Article in Biochemistry, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.1field-weighted citation impact, top 56% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 2 citations in OpenAlex.

  1. Structure-Function Relationship of the β-Hairpin ofInternational journal of molecular sciences · 2025
    Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Kathryn C ChiarolanzioDepartment of Chemistry, College of the Holy Cross, 1 College Street, Worcester, Massachusetts 01610, United States.
Jennifer M PusztayDepartment of Chemistry, College of the Holy Cross, 1 College Street, Worcester, Massachusetts 01610, United States.
Angel ChavezDepartment of Chemistry, College of the Holy Cross, 1 College Street, Worcester, Massachusetts 01610, United States.
Jing ZhaoDepartment of Biological Sciences, Rensselaer Polytechnic Institute, Troy, New York 12180, United States.ORCID 0000-0002-7031-3024
Jian XieDepartment of Biological Sciences, Rensselaer Polytechnic Institute, Troy, New York 12180, United States.ORCID 0000-0003-1381-9704
Chunyu WangDepartment of Biological Sciences, Rensselaer Polytechnic Institute, Troy, New York 12180, United States.ORCID 0000-0001-5165-7959
Kenneth V MillsDepartment of Chemistry, College of the Holy Cross, 1 College Street, Worcester, Massachusetts 01610, United States.ORCID 0000-0001-6052-308X
College of the Holy Cross · USRensselaer Polytechnic Institute · US

Funding

Structural Mechanisms of Hedgehog Autoprocessing in Physiology and DiseaseR01CA206592 · NCI · RENSSELAER POLYTECHNIC INSTITUTE · PI CALLAHAN, BRIAN PATRICK, WANG, CHUNYU · 2017 to 2021
$2.0M
The Regulation of Inteins: Adaptations in Extremophiles and Targets for Drug DiscoveryR15GM132817 · NIGMS · COLLEGE OF THE HOLY CROSS · PI MILLS, KENNETH V · 2019 to 2024
$723k
NCI NIH HHS R01 CA206592NIGMS NIH HHS R15 GM132817
6 · The paper itself

Abstract

Protein splicing is a post-translational process mediated by an intein, whereby the intein excises itself from a precursor protein with concomitant ligation of the two flanking polypeptides. The intein that interrupts the DNA polymerase II in the extreme hyperthermophile

Indexed as

InteinsProtein SplicingAmino Acid MotifsArchaeal ProteinsDNA Polymerase IIPyrococcus abyssiArchaeal ProteinsDNA Polymerase II

Identifiers

PMID32559373
PMCPMC7346874
OpenAlexW3036515761

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.