Evidence map›Paper›PMID 32559294›Full record

ArticleBlood advances2020

American Society of Hematology 2020 guidelines for sickle cell disease: management of acute and chronic pain.

Amanda M Brandow, C Patrick Carroll, Susan Creary, Ronisha Edwards-Elliott, Jeffrey Glassberg, Robert W Hurley, Abdullah Kutlar, Mohamed Seisa, Jennifer Stinson, John J Strouse and 3 more

3 registry-linked trialsAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Blood advances, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 3 registered trials, which are not on this map. Cited by 213 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
213citing papers in PubMed, 4 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06118853 nacompletednot on this mapstarted 2023, after this paper: background citation

Impact of Yoga and Gentle Massage Practices on Symptom Management in Patients Undergoing Hematopoietic Stem Cell Transplantation at the Hospital Israelita Albert Einstein

TypeinterventionalSponsorHospital Israelita Albert EinsteinRan2023 to 2025Enrolled35ConditionsHematopoietic Stem Cell Transplantation, Bone Marrow TransplantationArmsyoga or gentle massage plus standard treatment for HSCT
NCT06579703 phase4not yet recruitingnot on this mapstarted 2024, after this paper: background citation

Ketorolac Dosing for Acute Vaso-Occlusive Crisis in Pediatric Patients With Sickle Cell Disease

TypeinterventionalSponsorChildren's Blood and Cancer Center at Dell Children's Medical CenterRan2024 to 2028Enrolled102ConditionsSickle Cell Disease, Sickle Cell Crisis, Veno-occlusive DiseaseArmsKetorolac
NCT07188766 narecruitingnot on this mapstarted 2025, after this paper: background citation

Fluid Management in Sickle Cell Disease Vaso-occlusive Crisis: Restrictive Versus Liberal Strategies: A Randomized Controlled Trial (FLASC Trial)

TypeinterventionalSponsorImam Abdulrahman Bin Faisal UniversityRan2025 to 2028Enrolled394ConditionsSCD, Vaso Occlussive CrisisArmsSodium Chloride (NaCl) 0.9 %
3 · Its place in the literature

Who cites it

213 citing papers in PubMed, 4 syntheses or guidelines pooled it.

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  3. CDC Clinical Practice Guideline for Prescribing Opioids for Pain - United States, 2022.MMWR. Recommendations and reports : Morbidity and mortality weekly report. Recommendations and reports · 2022
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153 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Amanda M BrandowSection of Hematology/Oncology/Bone Marrow Transplantation, Department of Pediatrics, Medical College of Wisconsin, Milwaukee, WI.
C Patrick CarrollDepartment of Psychiatry and Behavioral Sciences, Johns Hopkins School of Medicine, Baltimore, MD.
Susan CrearyCenter for Innovation in Pediatric Practice, Division of Hematology, Oncology and Bone Marrow Transplant, Nationwide Children's Hospital, The Ohio State University School of Medicine, Columbus, OH.
Ronisha Edwards-ElliottDepartment of Pediatrics, University of Illinois at Chicago, Chicago, IL.
Jeffrey GlassbergDepartment of Emergency Medicine, Icahn School of Medicine at Mount Sinai, New York, NY.
Robert W HurleyDepartment of Anesthesiology and.
Abdullah KutlarCenter for Blood Disorders, Medical College of Georgia, Augusta University, Augusta, GA.
Mohamed SeisaMayo Clinic Evidence-based Practice Research Program, Robert D. and Patricia E. Kern Center for the Science of Health Care Delivery, Division of Health Care Policy and Research, Department of Health Sciences Research, Mayo Clinic, Rochester, MN.
Jennifer StinsonChild Health Evaluative Sciences, Research Institute, The Hospital for Sick Children, Lawrence S. Bloomberg Faculty of Nursing, University of Toronto, Toronto, ON, Canada.
John J StrouseDivision of Hematology, Department of Medicine, and.
Fouza YusufDepartment of Pediatrics, Medical College of Wisconsin, Milwaukee, WI.
William ZempskyDivision of Pain and Palliative Medicine, Connecticut Children's Medical Center, Department of Pediatrics, University of Connecticut School of Medicine, Hartford, CT; and.
Eddy LangDepartment of Emergency Medicine, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe management of acute and chronic pain for individuals living with sickle cell disease (SCD) is a clinical challenge. This reflects the paucity of clinical SCD pain research and limited understanding of the complex biological differences between acute and chronic pain. These issues collectively create barriers to effective, targeted interventions. Optimal pain management requires interdisciplinary care.

objectiveThese evidence-based guidelines developed by the American Society of Hematology (ASH) are intended to support patients, clinicians, and other health care professionals in pain management decisions for children and adults with SCD.

methodsASH formed a multidisciplinary panel, including 2 patient representatives, that was thoroughly vetted to minimize bias from conflicts of interest. The Mayo Evidence-Based Practice Research Program supported the guideline development process, including updating or performing systematic reviews. Clinical questions and outcomes were prioritized according to importance for clinicians and patients. The Grading of Recommendations Assessment, Development and Evaluation (GRADE) approach was used, including GRADE evidence-to-decision frameworks, to assess evidence and make recommendations, which were subject to public comment.

resultsThe panel reached consensus on 18 recommendations specific to acute and chronic pain. The recommendations reflect a broad pain management approach, encompassing pharmacological and nonpharmacological interventions and analgesic delivery.

conclusionsBecause of low-certainty evidence and closely balanced benefits and harms, most recommendations are conditional. Patient preferences should drive clinical decisions. Policymaking, including that by payers, will require substantial debate and input from stakeholders. Randomized controlled trials and comparative-effectiveness studies are needed for chronic opioid therapy, nonopioid therapies, and nonpharmacological interventions.

Indexed as

Anemia, Sickle CellChronic PainHematologyChildEvidence-Based MedicineHumansUnited States

Identifiers

PMID32559294
PMCPMC7322963

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.