ArticlePloS one2020
Structural dynamics and stability of corticocortical and thalamocortical axon terminals during motor learning.
Article in PloS one, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 24 citations in OpenAlex.
- Mechanism-guided identification of antidepressant G protein-coupled receptor drug targets.Cell · 2026Article
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- Experience-driven competition in neural reorganization after stroke.The Journal of physiology · 2025Review
- Dynamics of mature myelin.Nature neuroscience · 2024Review
- Synaptic correlates of the corticocortical circuit in motor learning.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2024Article
- Specific connectivity optimizes learning in thalamocortical loops.Cell reports · 2024Article
- Synaptic configuration and reconfiguration in the neocortex are spatiotemporally selective.Anatomical science international · 2024Review
- Layer 5 Intratelencephalic Neurons in the Motor Cortex Stably Encode Skilled Movement.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Article
- Reduced thalamic excitation to motor cortical pyramidal tract neurons in parkinsonism.Science advances · 2023Article
- Lanthanum Chloride Induces Axon Abnormality Through LKB1-MARK2 and LKB1-STK25-GM130 Signaling Pathways.Cellular and molecular neurobiology · 2023Article
- Quantitative Fluorescence Analysis Reveals Dendrite-Specific Thalamocortical Plasticity in L5 Pyramidal Neurons during Learning.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Article
- Cortical circuit dynamics underlying motor skill learning: from rodents to humans.Frontiers in molecular neuroscience · 2023Review
- Presynaptic supervision of cortical spine dynamics in motor learning.Science advances · 2022Article
- Synaptic modifications in learning and memory - A dendritic spine story.Seminars in cell & developmental biology · 2022Review
- Regional brain atrophy in patients with chronic ankle instability: A voxel-based morphometry study.Frontiers in neuroscience · 2022Article
- Shedding light on learning and memory: optical interrogation of the synaptic circuitry.Current opinion in neurobiology · 2021Review
- Resting Theta/Beta Ratios Mediate the Relationship Between Motor Competence and Inhibition in Children With Attention Deficit/Hyperactivity Disorder.Frontiers in psychology · 2021Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Synaptic plasticity is the cellular basis of learning and memory. When animals learn a novel motor skill, synaptic modifications are induced in the primary motor cortex (M1), and new postsynaptic dendritic spines relevant to motor memory are formed in the early stage of learning. However, it is poorly understood how presynaptic axonal boutons are formed, eliminated, and maintained during motor learning, and whether long-range corticocortical and thalamocortical axonal boutons show distinct structural changes during learning. In this study, we conducted two-photon imaging of presynaptic boutons of long-range axons in layer 1 (L1) of the mouse M1 during the 7-day learning of an accelerating rotarod task. The training-period-averaged rate of formation of boutons on axons projecting from the secondary motor cortical area increased, while the average rate of elimination of those from the motor thalamus (thalamic boutons) decreased. In particular, the elimination rate of thalamic boutons during days 4-7 was lower than that in untrained mice, and the fraction of pre-existing thalamic boutons that survived until day 7 was higher than that in untrained mice. Our results suggest that the late stabilization of thalamic boutons in M1 contributes to motor skill learning.
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