ArticlePloS one2020
Sanguinarine modulate gut microbiome and intestinal morphology to enhance growth performance in broilers.
Article in PloS one, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers.
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Who cites it
40 citing papers in PubMed, 72 citations in OpenAlex.
- Dietary Sanguinarine MitigatesLife (Basel, Switzerland) · 2026Article
- Phytogenic effects of Brachiaria decumbens saponin extract on growth performance, immune response, and telomere dynamics in broiler chickens under tropical conditions.Tropical animal health and production · 2026Article
- Intestinal morphometric changes associated with the use of non-antibiotic feed additives in broiler chicks challenged withJournal of animal science and technology · 2026Article
- Exploring the impact of sanguinarine on lamb immunity based on gut microbiota and metabolomics.Frontiers in veterinary science · 2026Article
- Effects of Glucose Oxidase andMetabolites · 2025Article
- Effects of Cordyceps militaris solid medium on the growth performance, immunity parameters and intestinal health of broilers.Animal bioscience · 2025Article
- Dihydrosanguinarine enhances tryptophan metabolism and intestinal immune function via AhR pathway activation in broilers.Journal of animal science and biotechnology · 2025Article
- Captive rearing effects on the methylome of Atlantic salmon after oceanic migration: Sex-specificity and intergenerational stability.Molecular ecology resources · 2025Article
- Stomata-targeted nanocarriers enhance plant defense against pathogen colonization.Nature communications · 2025Article
- Identification of Therapeutic Targets for Hyperuricemia: Systematic Genome-Wide Mendelian Randomization and Colocalization Analysis.Biomedicines · 2025Article
- The Gut Health Revolution: Herbs and Dietary Phytochemicals in Balancing Gut Microbiota for Optimal Human Health.Current pharmaceutical biotechnology · 2025Review
- Phytobiotics in poultry: revolutionizing broiler chicken nutrition with plant-derived gut health enhancers.Journal of animal science and biotechnology · 2024Review
- Macleaya cordata extract improves egg quality by altering gut health and microbiota in laying hens.Poultry science · 2024Article
- Dietary sanguinarine supplementation improves the growth performance and intestinal immunity of broilers.Animal nutrition (Zhongguo xu mu shou yi xue hui) · 2024Article
- Combined Effect ofAnimals : an open access journal from MDPI · 2024Article
- Article
- Intein-mediated temperature control for complete biosynthesis of sanguinarine and its halogenated derivatives in yeast.Nature communications · 2024Article
- Effects of a dietary isoquinoline alkaloids blend on gut antioxidant capacity and gut barrier of young broilers.Poultry science · 2024Article
- Dietary supplementation with Macleaya cordata extract alleviates intestinal injury in broiler chickens challenged with lipopolysaccharide by regulating gut microbiota and plasma metabolites.Frontiers in immunology · 2024Article
- Protective Application of Chinese Herbal Compounds and Formulae in Intestinal Inflammation in Humans and Animals.Molecules (Basel, Switzerland) · 2023Review
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Sanguinarine is a bioactive compound as a quaternary benzophenanthridine alkaloid from plant of the Macleaya cordata, Papaveraceae family. The present study was conducted to investigate the effects of dietary sanguinarine supplementation on growth performance, serum biochemistry parameters, intestinal mucosal morphology and gut microbiome in yellow feathered broilers. Two hundred and seventy 1-d-old female broilers were randomly assigned to 3 treatments ① Basal diet (NG); ② Basal diet containing bacitracin methylene disalicylate (50mg/Kg diet) (ANT); ③ Basal diet containing sanguinarine (0.7 mg/ kg of feed) (SAG). The statistical results showed that dietary sanguinarine supplementation enhanced growth performance and decreased glucose, uric acid as well as urea nitrogen levels of broilers at 28d of age (P<0.05). The 16S rRNA gene sequence analysis revealed that sanguinarine significantly decreased the species from the phyla Bacteroidetes, and increased the species from phyla Firmicutes. Moreover, dietary sanguinarine supplementation improved mucosal morphology to achieve higher ratio of intestinal villus height to crypt depth (P < 0.05), and decreased the concentrations of TNF-α and IL-4 in jejunum mucosal. This study demonstrated that sanguinarine supplementation in the diet of yellow feathered broilers improved intestinal morphology and microbiota community structure to promote growth performance on 1-28d.
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