ArticlePLoS biology2020
Dopamine modulates subcortical responses to surprising sounds.
Article in PLoS biology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 28 papers.
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Who cites it
28 citing papers in PubMed.
- A Dual Prediction Error Populations Model of Schizophrenia Spectrum Disorders: Bridging NMDA Hypofunction and Gain Hyperfunction.Schizophrenia bulletin · 2026Article
- Dopamine in the Nucleus Accumbens Signals Salience of Auditory Deviance.The European journal of neuroscience · 2026Article
- Sex- and etiology-specific effects on predictive processing in the inferior colliculus of two rat models of autism.Communications biology · 2026Article
- The predictive processing embodied in brain conditions: the role of precision.Frontiers in psychology · 2026Article
- Neuronal mismatch responses to auditory stimuli in the dorsal hippocampus of anesthetized rats.Communications biology · 2025Article
- Contextual auditory processing in the inferior colliculus is affected in a sex- and age-dependent manner in the valproic acid-induced rat model of autism.PLoS biology · 2025Article
- A midbrain circuit mechanism for noise-induced negative valence coding.Nature communications · 2025Article
- Brain network dynamics predict moments of surprise across contexts.Nature human behaviour · 2025Article
- Segregated input to thalamic areas that project differently to core and shell auditory cortical fields.iScience · 2025Article
- An active inference account of stuttering behavior.Frontiers in human neuroscience · 2025Article
- Mating proximity blinds threat perception.Nature · 2024Article
- Surprising sounds influence risky decision making.Nature communications · 2024Article
- Two Prediction Error Systems in the Nonlemniscal Inferior Colliculus: "Spectral" and "Nonspectral".The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- Article
- Unsigned surprise but not reward magnitude modulates the integration of motor elements during actions.Scientific reports · 2023Article
- Neural Circuitry of Salience and Reward Processing in Psychosis.Biological psychiatry global open science · 2023Review
- The Neurobiology of Pathological Fatigue: New Models, New Questions.The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry · 2022Article
- Altered Pain Processing Associated with Administration of Dopamine Agonist and Antagonist in Healthy Volunteers.Brain sciences · 2022Article
- Alzheimer's Disease, Hearing Loss, and Deviance Detection.Frontiers in neuroscience · 2022Article
- Visual Influences on Auditory Behavioral, Neural, and Perceptual Processes: A Review.Journal of the Association for Research in Otolaryngology : JARO · 2021Review
Corrections and comments
- Erratum issued
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Dopamine guides behavior and learning through pleasure, according to classic understanding. Dopaminergic neurons are traditionally thought to signal positive or negative prediction errors (PEs) when reward expectations are, respectively, exceeded or not matched. These signed PEs are quite different from the unsigned PEs, which report surprise during sensory processing. But mounting theoretical accounts from the predictive processing framework postulate that dopamine, as a neuromodulator, could potentially regulate the postsynaptic gain of sensory neurons, thereby scaling unsigned PEs according to their expected precision or confidence. Despite ample modeling work, the physiological effects of dopamine on the processing of surprising sensory information are yet to be addressed experimentally. In this study, we tested how dopamine modulates midbrain processing of unexpected tones. We recorded extracellular responses from the rat inferior colliculus to oddball and cascade sequences, before, during, and after the microiontophoretic application of dopamine or eticlopride (a D2-like receptor antagonist). Results demonstrate that dopamine reduces the net neuronal responsiveness exclusively to unexpected sensory input without significantly altering the processing of expected input. We conclude that dopaminergic projections from the thalamic subparafascicular nucleus to the inferior colliculus could encode the expected precision of unsigned PEs, attenuating via D2-like receptors the postsynaptic gain of sensory inputs forwarded by the auditory midbrain neurons. This direct dopaminergic modulation of sensory PE signaling has profound implications for both the predictive coding framework and the understanding of dopamine function.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.