Evidence map›Paper›PMID 32559057›Full record

ArticleACS nano2020

Magnetic Vortex Nanodiscs Enable Remote Magnetomechanical Neural Stimulation.

Danijela Gregurec, Alexander W Senko, Andrey Chuvilin, Pooja D Reddy, Ashwin Sankararaman, Dekel Rosenfeld, Po-Han Chiang, Francisco Garcia, Ian Tafel, Georgios Varnavides and 2 more

Open access · greenAbstract read
In one paragraph

Article in ACS nano, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 64 papers.

0numbers the graph read from it
0cells of the map it votes in
64citing papers in PubMed
7.6field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

64 citing papers in PubMed, 141 citations in OpenAlex.

  1. Article
  2. Review
  3. NongeneticACS nano · 2026
    Article
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  17. Genetics-Based Targeting Strategies for Precise Neuromodulation.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025
    Review
  18. Article
  19. Article
  20. Article

4 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 6 institutions in 2 countries.

Danijela GregurecResearch Laboratory of Electronics, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, United States.
Alexander W SenkoResearch Laboratory of Electronics, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, United States.
Andrey ChuvilinCIC nanoGUNE, E20018 San Sebastián, Spain.
Pooja D ReddyDepartment of Materials Science and Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, United States.
Ashwin SankararamanResearch Laboratory of Electronics, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, United States.
Dekel RosenfeldResearch Laboratory of Electronics, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, United States.
Po-Han ChiangResearch Laboratory of Electronics, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, United States.
Francisco GarciaMcGovern Institute for Brain Research, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, United States.
Ian TafelDepartment of Neurosurgery, Brigham and Women's Hospital, Boston, Massachusetts 02115, United States.
Georgios VarnavidesResearch Laboratory of Electronics, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, United States.
Eugenia CiocanDepartment of Engineering and Physical Sciences, Bunker Hill Community College, Boston, Massachusetts 02129, United States.
Polina AnikeevaResearch Laboratory of Electronics, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, United States.ORCID 0000-0001-6495-5197
McGovern Institute for Brain Research · USMassachusetts Institute of Technology · USBrigham and Women's Hospital · USBunker Hill Community College · USHarvard University · USIkerbasque · ES

Funding

Multi-Site Non-Invasive Magnetothermal Excitation and Inhibition of Deep Brain StructuresR01MH111872 · NIMH · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI ANIKEEVA, POLINA O, PRALLE, ARND · 2016 to 2019
$3.6M
NIMH NIH HHS R01 MH111872
6 · The paper itself

Abstract

Magnetic nanomaterials in magnetic fields can serve as versatile transducers for remote interrogation of cell functions. In this study, we leveraged the transition from vortex to in-plane magnetization in iron oxide nanodiscs to modulate the activity of mechanosensory cells. When a vortex configuration of spins is present in magnetic nanomaterials, it enables rapid control over their magnetization direction and magnitude. The vortex configuration manifests in near zero net magnetic moment in the absence of a magnetic field, affording greater colloidal stability of magnetic nanomaterials in suspensions. Together, these properties invite the application of magnetic vortex particles as transducers of externally applied minimally invasive magnetic stimuli in biological systems. Using magnetic modeling and electron holography, we predict and experimentally demonstrate magnetic vortex states in an array of colloidally synthesized magnetite nanodiscs 98-226 nm in diameter. The magnetic nanodiscs applied as transducers of torque for remote control of mechanosensory neurons demonstrated the ability to trigger Ca

Indexed as

Magnetic FieldsNeuronsHEK293 CellsHumanscellular signalingelectron holographymagnetic nanoparticlesmagnetic vortexmechanosensitive ion channelsmechanotransductionneuromodulation

Identifiers

PMID32559057
PMCPMC8592276
OpenAlexW3036989405

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.