Evidence map›Paper›PMID 32558263›Full record

ArticlePigment cell & melanoma research2020

Heme oxygenase promotes B-Raf-dependent melanosphere formation.

Kimberly J Jasmer, Jie Hou, Philip Mannino, Jianlin Cheng, Mark Hannink

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Pigment cell & melanoma research, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 1 pooled it
0.7field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 1 synthesis or guideline pooled it, 10 citations in OpenAlex.

  1. The dual role of Nrf2 in melanoma: a systematic review.BMC molecular and cell biology · 2023
    Pooled it
  2. Review
  3. Article
  4. Article
  5. Article
  6. Heme oxygenase 1: a novel oncogene in multiple gynecological cancers.International journal of biological sciences · 2021
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Kimberly J JasmerDivision of Biological Sciences, University of Missouri, Columbia, Missouri, USA.ORCID 0000-0002-8669-428X
Jie HouComputer Science Department, University of Missouri, Columbia, Missouri, USA.
Philip ManninoChristopher Bond Life Sciences Center, University of Missouri, Columbia, Missouri, USA.
Jianlin ChengComputer Science Department, University of Missouri, Columbia, Missouri, USA.
Mark HanninkChristopher Bond Life Sciences Center, University of Missouri, Columbia, Missouri, USA.ORCID 0000-0002-7319-6572
University of Missouri · US

Funding

The Interactions Core/Mark McintoshP50AT006273 · NCCIH · UNIVERSITY OF MISSOURI-COLUMBIA · PI LUBAHN, DENNIS B · 2010 to 2014
$7.4M
NCCIH NIH HHS P50 AT006273NIH HHS NIH 1 P50 AT006273
6 · The paper itself

Abstract

Biosynthesis and degradation of heme, an iron-bound protoporphyrin molecule utilized by a wide variety of metabolic processes, are tightly regulated. Two closely related enzymes, heme oxygenase 1 (HMOX1) and heme oxygenase 2 (HMOX2), degrade free heme to produce carbon monoxide, Fe

Indexed as

Cell AdhesionCell Line, TumorCell ProliferationExtracellular MatrixFocal AdhesionsGene Expression RegulationHEK293 CellsHeme Oxygenase (Decyclizing)HumansMaleMelanocytesMutationNF-E2-Related Factor 2OncogenesProto-Oncogene MasProto-Oncogene Proteins B-rafBRAF protein, humancobaltiprotoporphyrinHeme Oxygenase (Decyclizing)MAS1 protein, humanNFE2L2 protein, humanNF-E2-Related Factor 2Proto-Oncogene MasProto-Oncogene Proteins B-rafProtoporphyrinsantioxidantBach1extracellular matrix proteinsHeme Oxygenase-1melanomamelanosphereneoplastic stem cellsNFE2L2proto-oncogene proteins B-Rafreactive oxygen species

Identifiers

PMID32558263
PMCPMC7572722
OpenAlexW3036134888

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.