ArticleBasic & clinical pharmacology & toxicology2020
Placental transfer of pesticides studied in human placental perfusion.
Article in Basic & clinical pharmacology & toxicology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
10 citing papers in PubMed, 24 citations in OpenAlex.
- Prenatal Exposure to Organochlorine Compounds and Other Pesticides: A Systematic Review of Neonatal Health Outcomes.Maternal-fetal medicine (Wolters Kluwer Health, Inc.) · 2026Article
- Pregnancy, Childcare, and Pesticides: Understanding the Health Risks of Women and Children in Small-Scale Horticulture in Tanzania.Qualitative health research · 2025Article
- Spatiotemporal Angiogenic Patterns in the Development of the Mouse Fetal Blood-Brain Barrier System During Pregnancy.International journal of molecular sciences · 2025Article
- Pyrethroid pesticide exposure and placental effects.Molecular and cellular endocrinology · 2023Review
- The toxicokinetics of acute paraquat poisoning in specific patients: a case series.The Journal of international medical research · 2022Article
- Association of Prenatal Exposure to Endocrine-Disrupting Chemicals With Liver Injury in Children.JAMA network open · 2022Article
- Maternal and fetal tissue distribution of α-cypermethrin and permethrin in pregnant CD-1 mice.Environmental advances · 2022Article
- Reproductive Health Risks Associated with Occupational and Environmental Exposure to Pesticides.International journal of environmental research and public health · 2021Review
- Evaluation of Placental Transfer and Tissue Distribution ofFrontiers in pediatrics · 2021Article
- Placental transfer of pesticides studied in human placental perfusion.Basic & clinical pharmacology & toxicology · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 2 institutions in 1 country.
Funding
Abstract
To investigate the transplacental transport of pesticides, the pyrethroid cypermethrin and the fungicide azoles, propiconazole and bitertanol were tested in the placental perfusion model. Cypermethrin, propiconazole and bitertanol were also tested in the BeWo cell transfer model. The pesticides were chosen with the selection criteria: use in Denmark, significant treated areas and knowledge on hormone-disrupting effects. Propiconazole and bitertanol showed rapid transfer and adsorbance to the system in both placental perfusion and BeWo cell system, whereas cypermethrin had a slower transport across the placental cell layers in the two models. There was no difference between data of the single pesticides and their mixture in either placental perfusion or BeWo cell transfer model. Both the placental perfusion model and the BeWo cell model metabolized the pesticides and released metabolites into both foetal and maternal circulation. Using human exposure models, this study shows the potential exposure of the human foetus to pesticides cypermethrin, propiconazole and bitertanol and their metabolites.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.