Evidence map›Paper›PMID 32557809›Full record

ArticleFASEB journal : official publication of the Federation of American Societies for Experimental Biology2020

Osteocytes control myeloid cell proliferation and differentiation through Gsα-dependent and -independent mechanisms.

Ehab Azab, Kevin Brown Chandler, Yuhei Uda, Ningyuan Sun, Amira Hussein, Raghad Shuwaikan, Veronica Lu, Catherine E Costello, Mark E McComb, Paola Divieti Pajevic

Open access · bronzeAbstract read
In one paragraph

Article in FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
1.0field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 13 citations in OpenAlex.

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  11. The Development of Molecular Biology of Osteoporosis.International journal of molecular sciences · 2021
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Ehab AzabDepartment of Translational Dental Medicine, Henry M. Goldman School of Dental Medicine, Boston University, Boston, MA, USA.
Kevin Brown ChandlerCenter for Biomedical Mass Spectrometry, School of Medicine, Boston University, Boston, MA, USA.
Yuhei UdaDepartment of Translational Dental Medicine, Henry M. Goldman School of Dental Medicine, Boston University, Boston, MA, USA.
Ningyuan SunDepartment of Translational Dental Medicine, Henry M. Goldman School of Dental Medicine, Boston University, Boston, MA, USA.
Amira HusseinDepartment of Orthopedics, School of Medicine, Boston University, Boston, MA, USA.
Raghad ShuwaikanDepartment of Translational Dental Medicine, Henry M. Goldman School of Dental Medicine, Boston University, Boston, MA, USA.
Veronica LuDepartment of Translational Dental Medicine, Henry M. Goldman School of Dental Medicine, Boston University, Boston, MA, USA.
Catherine E CostelloCenter for Biomedical Mass Spectrometry, School of Medicine, Boston University, Boston, MA, USA.
Mark E McCombCenter for Biomedical Mass Spectrometry, School of Medicine, Boston University, Boston, MA, USA.
Paola Divieti PajevicDepartment of Translational Dental Medicine, Henry M. Goldman School of Dental Medicine, Boston University, Boston, MA, USA.
Boston University · US

Funding

Project-005UL1TR001430 · NCATS · BOSTON UNIVERSITY MEDICAL CAMPUS · PI BAIR-MERRITT, MEGAN H, CENTER, DAVID M. · 2015 to 2024
$52.3M
Mass Spectrometry Resource for Biology and MedicineP41GM104603 · NIGMS · BOSTON UNIVERSITY MEDICAL CAMPUS · PI COSTELLO, CATHERINE E. · 2012 to 2017
$10.4M
Legacy Support During Closure of the Mass Spectrometry Resource for Biology and MedicineR24GM134210 · NIGMS · BOSTON UNIVERSITY MEDICAL CAMPUS · PI COSTELLO, CATHERINE E. · 2019 to 2021
$2.1M
Effects of osteocyte specific Gs alpha signaling on bone mass and hematopoiesisR01AR060221 · NIAMS · MASSACHUSETTS GENERAL HOSPITAL · PI DIVIETI PAJEVIC, PAOLA · 2011 to 2015
$1.9M
NCATS NIH HHS UL1 TR001430NIAMS NIH HHS R01 AR060221NIGMS NIH HHS P41 GM104603NIGMS NIH HHS R24 GM134210
6 · The paper itself

Abstract

Osteocytes, the bone cells embedded in the mineralized matrix, control bone modeling, and remodeling through direct contact with adjacent cells and via paracrine and endocrine factors that affect cells in the bone marrow microenvironment or distant organs. Osteocytes express numerous G protein-coupled receptors (GPCRs) and thus mice lacking the stimulatory subunit of G-protein (Gsα) in osteocytes (Dmp1-Gsα

Indexed as

AnimalsBone Diseases, MetabolicBone MarrowBone ResorptionCell DifferentiationCell LineCell ProliferationCulture Media, ConditionedExtracellular Matrix ProteinsGTP-Binding Protein alpha Subunits, GsMiceMice, Inbred C57BLMyeloid CellsMyelopoiesisOsteoclastsOsteocytesCulture Media, ConditionedExtracellular Matrix ProteinsGTP-Binding Protein alpha Subunits, GsGsαmacrophagesmyeloid cellsneuropilin-1osteoclastosteocytes

Identifiers

PMID32557809
PMCPMC7688590
OpenAlexW3036536530

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.