SynthesisActa paediatrica (Oslo, Norway : 1992)2020
Novel coronavirus infection (COVID-19) in children younger than one year: A systematic review of symptoms, management and outcomes.
Synthesis in Acta paediatrica (Oslo, Norway : 1992), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
29 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Pooled it
- Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Setting-specific Transmission Rates: A Systematic Review and Meta-analysis.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2021Pooled it
- Novel coronavirus infection (COVID-19) in children younger than one year: A systematic review of symptoms, management and outcomes.Acta paediatrica (Oslo, Norway : 1992) · 2020Pooled it
- Comprehensive insights into pathogen distribution, clinical features, and outcomes in pediatric severe pneumonia.Frontiers in cellular and infection microbiology · 2025Article
- COVID-19 among infants: key clinical features and remaining controversies.Clinical and experimental pediatrics · 2024Article
- Transplacental Transfer of SARS-CoV-2 Receptor-Binding Domain IgG Antibodies from Mothers to Neonates in a Cohort of Pakistani Unvaccinated Mothers.Biomedicines · 2023Article
- Test positivity and clinical presentation of COVID-19 in Mozambican infants hospitalized during the second wave of the pandemic in 2021.The Pan African medical journal · 2023Article
- Favorable Outcome in Infants Hospitalized With COVID-19: Single Center Experience from Athens, Greece.Indian pediatrics · 2022Article
- Clinical presentation of COVID-19 at the time of testing and factors associated with pre-symptomatic cases in Cameroon.IJID regions · 2022Article
- Clinical and Laboratory Findings of SARS-CoV-2 Infection in Children Younger than 6 Months Old: Neutropenia is More Common Not Lymphopenia.Journal of tropical pediatrics · 2022Article
- Characteristics and outcomes of SARS-CoV-2 infection in Victorian children at a tertiary paediatric hospital.Journal of paediatrics and child health · 2022Article
- Clinical features and outcomes of coronavirus disease 2019 in early infants in Japan: A case series and literature review.Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy · 2022Review
- Article
- Management of severe neonatal respiratory distress due to vertical transmission of severe acute respiratory syndrome coronavirus 2: a case report.Journal of medical case reports · 2022Article
- Incidental occurrence of neutropenia in children hospitalised for COVID-19.Italian journal of pediatrics · 2022Article
- SARS-CoV-2 specific antibody trajectories in mothers and infants over two months following maternal infection.Frontiers in immunology · 2022Article
- Mental Health Changes in Older Adults in Response to the COVID-19 Pandemic: A Longitudinal Study in Mexico.Frontiers in public health · 2022Article
- Comment on "Novel coronavirus infection (COVID-19) in children younger than one year: A systematic review of symptoms, management and outcomes".Acta paediatrica (Oslo, Norway : 1992) · 2022Article
- Clinical Profile, Hospital Course and Outcome of Children with COVID-19.Indian journal of pediatrics · 2021Article
- Prevalence and determinants of symptomatic COVID-19 infection among children and adolescents in Qatar: a cross-sectional analysis of 11 445 individuals.Epidemiology and infection · 2021Article
Corrections and comments
- Commented on by
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimThe aim of this systematic review was to evaluate the clinical characteristics of COVID-19 in neonates and children under one year of age.
methodsA systematic literature review of the MEDLINE, PubMed, CINAHL, Embase and EBSCO databases was carried out for studies from January 1, 2020, to April 7, 2020. We included all papers that addressed clinical manifestations, laboratory results, imaging findings and outcomes in infants and neonates.
resultsOur search identified 77 peer-reviewed papers, and 18 papers covering 160 infants were reviewed. One paper was from Vietnam, and the other 17 were from China: eight were cross-sectional studies, eight were case reports, one was a case series, and one was a prospective cohort study. The most common clinical symptoms were fever (54%) and cough (33%). Most infants were treated symptomatically, with frequent use of various empirical medications. Infants and neonates tended to have more severe COVID-19 disease than older children: 11 (7%) were admitted to intensive care and one infant died. The mortality rate was 0.006%, with favourable outcomes in most cases.
conclusionInfants and neonates were more vulnerable to more severe COVID-19 disease than older children, but morbidity and mortality were low.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.