ArticleMagnetic resonance in medicine2020
Comparison of BOLD and CBV using 3D EPI and 3D GRASE for cortical layer functional MRI at 7 T.
Article in Magnetic resonance in medicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
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Who cites it
32 citing papers in PubMed.
- Functional Imaging of Hippocampal Layers Using VASO and BOLD on the Next Generation (NexGen) 7T Scanner.Human brain mapping · 2026Article
- Testing circuit-level theories of consciousness in humans.Trends in cognitive sciences · 2026Review
- Mapping dynamics in neuronal activation and molecular connectivity with functional PET.Frontiers in neuroscience · 2026Review
- Functional imaging of hippocampal layers using VASO and BOLD on the Next Generation (NexGen) 7T Scanner.bioRxiv : the preprint server for biology · 2025Article
- The laminar pattern of proprioceptive activation in human primary motor cortex.Cerebral cortex (New York, N.Y. : 1991) · 2025Article
- Layer-specific BOLD effects in gradient and spin-echo acquisitions in somatosensory cortex.Magnetic resonance in medicine · 2025Article
- Characterizing BOLD activation patterns in the human hippocampus with laminar fMRI.Imaging neuroscience (Cambridge, Mass.) · 2025Article
- Imaging joy with generalized slice dithered enhanced resolution and SWAT reconstruction: 3T high spatial-temporal resolution fMRI.Frontiers in neuroimaging · 2025Article
- Mapping curvature domains in human V4 using CBV-sensitive layer-fMRI at 3T.Frontiers in neuroscience · 2025Article
- Laminar multi-contrast fMRI at 7T allows differentiation of neuronal excitation and inhibition underlying positive and negative BOLD responses.medRxiv : the preprint server for health sciences · 2024Article
- Motion compensated structured low-rank reconstruction for 3D multi-shot EPI.Magnetic resonance in medicine · 2024Article
- Characterisation of laminar and vascular spatiotemporal dynamics of CBV and BOLD signals using VASO and ME-GRE at 7T in humans.bioRxiv : the preprint server for biology · 2024Article
- Characterisation of laminar and vascular spatiotemporal dynamics of CBV and BOLD signals using VASO and ME-GRE at 7T in humans.Imaging neuroscience (Cambridge, Mass.) · 2024Article
- Advancements in MR hardware systems and magnetic field control: BPsychoradiology · 2024Review
- Laminar multi-contrast fMRI at 7T allows differentiation of neuronal excitation and inhibition underlying positive and negative BOLD responses.Imaging neuroscience (Cambridge, Mass.) · 2024Article
- A comparative analysis of the sensitivity and BOLD contamination of the VASO response at 3 Tesla: ME-DEPICTING vs. ME-EPI readouts.Imaging neuroscience (Cambridge, Mass.) · 2024Article
- Imaging the columnar functional organization of human area MT+ to axis-of-motion stimuli using VASO at 7 Tesla.Cerebral cortex (New York, N.Y. : 1991) · 2023Article
- Modelling the depth-dependent VASO and BOLD responses in human primary visual cortex.Human brain mapping · 2023Article
- Evaluating the capabilities and challenges of layer-fMRI VASO at 3T.Aperture neuro · 2023Article
- Cerebral blood volume sensitive layer-fMRI in the human auditory cortex at 7T: Challenges and capabilities.PloS one · 2023Article
Corrections and comments
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6 authors.
Funding
Abstract
purposeFunctional MRI (fMRI) at the mesoscale of cortical layers and columns requires both sensitivity and specificity, the latter of which can be compromised if the imaging method is affected by vascular artifacts, particularly cortical draining veins at the pial surface. Recent studies have shown that cerebral blood volume (CBV) imaging is more specific to the actual laminar locus of neural activity than BOLD imaging using standard gradient-echo EPI sequences. Gradient and spin-echo (GRASE) BOLD imaging has also shown greater specificity when compared with standard gradient-echo EPI BOLD. Here we directly compare CBV and BOLD contrasts in high-resolution imaging of the primary motor cortex for laminar functional MRI in four combinations of signal labeling, CBV using slice-selective slab-inversion vascular space occupancy (VASO) and BOLD, each with 3D gradient-echo EPI and zoomed 3D-GRASE image readouts.
methodsActivations were measured using each sequence and contrast combination during a motor task. Activation profiles across cortical depth were measured to assess the sensitivity and specificity (pial bias) of each method.
resultsBoth CBV imaging using gradient-echo 3D-EPI and BOLD imaging using 3D-GRASE show similar specificity and sensitivity and are therefore useful tools for mesoscopic functional MRI in the human cortex. The combination of GRASE and VASO did not demonstrate high levels of sensitivity, nor show increased specificity.
conclusionThree-dimensional EPI with VASO contrast and 3D-GRASE with BOLD contrast both demonstrate sufficient sensitivity and specificity for laminar functional MRI to be used by neuroscientists in a wide range of investigations of depth-dependent neural circuitry in the human brain.
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