ArticleHistopathology2020
Intraoperative assessment and reporting of radical prostatectomy specimens to guide nerve-sparing surgery in prostate cancer patients (NeuroSAFE).
Article in Histopathology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.
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14 citing papers in PubMed, 1 synthesis or guideline pooled it, 31 citations in OpenAlex.
- Neurovascular structure-adjacent frozen-section examination (NeuroSAFE) during robot-assisted radical prostatectomy: a systematic review and meta-analysis of comparative studies.Prostate cancer and prostatic diseases · 2025Pooled it
- 3D-printed model for resection of positive surgical margins in robot-assisted prostatectomy.BJU international · 2025Trial
- Intraoperative Techniques Aiding Margin Assessment and Nerve Sparing During Robot-Assisted Radical Prostatectomy.Cancers · 2026Review
- Feasibility and workflow analysis of confocal microscopy in robot-assisted prostatectomy.BJU international · 2026Article
- The cost-effectiveness of intraoperative margin assessment strategies during radical prostatectomy.BJU international · 2026Article
- Next-Generation Nerve-Sparing Techniques in Robotic Radical Prostatectomy: A Contemporary Review.Current urology reports · 2025Review
- Neurovascular Structure-Adjacent Frozen-Section Examination (NeuroSAFE) Technique of Nerve-Sparing Robot-Assisted Radical Prostatectomy (RARP) in Indian Scenario: Technique, Feasibility, and Early Outcomes.Indian journal of surgical oncology · 2024Article
- Predicting contralateral extraprostatic extension in unilateral high-risk prostate cancer: a multicentric external validation study.World journal of urology · 2024Article
- Stimulated Raman Histology Interpretation by Artificial Intelligence Provides Near-Real-Time Pathologic Feedback for Unprocessed Prostate Biopsies.The Journal of urology · 2024Article
- NeuroSAFE in radical prostatectomy increases the rate of nerve-sparing surgery without affecting oncological outcome.BJU international · 2022Review
- Neurovascular structure-adjacent frozen-section examination robotic-assisted radical prostatectomy: outcomes from 500 consecutive cases in the UK.Journal of robotic surgery · 2022Article
- Article
- Cerenkov Luminescence Imaging in Prostate Cancer: Not the Only Light That Shines.Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2022Article
- Intraoperative assessment and reporting of radical prostatectomy specimens to guide nerve-sparing surgery in prostate cancer patients (NeuroSAFE).Histopathology · 2020Article
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14 authors at 3 institutions in 1 country.
Funding
Abstract
aimsRadical prostatectomy for prostate cancer is frequently complicated by urinary incontinence and erectile dysfunction. Nerve-sparing surgery reduces the risk of postoperative complications and can be optimised by the use of intraoperative frozen sections of the adjacent neurovascular structure (NeuroSAFE). The aims of this study were to evaluate the pathological outcomes of the NeuroSAFE technique and to develop a comprehensive algorithm for intraoperative clinical decision-making. METHODS AND
resultsBetween September 2018 and May 2019, 491 NeuroSAFE procedures were performed in 258 patients undergoing radical prostatectomy; 74 of 491 (15.1%) NeuroSAFE specimens had positive surgical margins. As compared with the corresponding paraffin sections, NeuroSAFE had a positive predictive value and negative predictive value of 85.1% and 95.4%, respectively. In 72.2% of secondary neurovascular bundle resections prompted by a NeuroSAFE positive surgical margin, no tumour was present. These cases more often had a positive surgical margin of ≤1 mm (48.7% versus 20.0%; P = 0.001) and only one positive slide (69.2% versus 33.3%; P = 0.008). None of the nine patients with Gleason pattern 3 at the surgical margin, a positive surgical margin length of ≤1 mm and one positive slide had tumour in the secondary resection.
conclusionsThis study provides a systematic reporting template for pathological intraoperative NeuroSAFE evaluation, supporting intraoperative clinical decision-making and comparison between prostate cancer operation centres.
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