Evidence map›Paper›PMID 32557064›Full record

ArticleEnvironmental science and pollution research international2020

Interaction effect of polycyclic aromatic hydrocarbon metabolites and cadmium on semen quality in nonsmokers.

Yihao Shi, Pokhrel Gaurab, Wangcheng Wang, Jianqiao Yan, Zhongyang Sun, Yucong Zhang, Jihong Liu, Xiaming Liu, Dan Zheng

Abstract read
PubMed Publisher
In one paragraph

Article in Environmental science and pollution research international, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.5field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 7 citations in OpenAlex.

  1. Review
  2. Impact of Heavy Metals on Human Male Fertility-An Overview.Antioxidants (Basel, Switzerland) · 2021
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Yihao Shi *MOE Key Laboratory of Environment and Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, Hubei, China.
Pokhrel Gaurab *Tongji Hospital of Tongji Medical College of Huazhong University of Science and Technology, Wuhan, 430030, Hubei, China.
Wangcheng WangMOE Key Laboratory of Environment and Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, Hubei, China.
Jianqiao YanMOE Key Laboratory of Environment and Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, Hubei, China.
Zhongyang SunMOE Key Laboratory of Environment and Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, Hubei, China.
Yucong ZhangTongji Hospital of Tongji Medical College of Huazhong University of Science and Technology, Wuhan, 430030, Hubei, China.
Jihong LiuTongji Hospital of Tongji Medical College of Huazhong University of Science and Technology, Wuhan, 430030, Hubei, China.
Xiaming LiuTongji Hospital of Tongji Medical College of Huazhong University of Science and Technology, Wuhan, 430030, Hubei, China. xmingliu@hust.edu.cn.
Dan ZhengMOE Key Laboratory of Environment and Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, Hubei, China. zhengdan@mail.hust.edu.cn.
Huazhong University of Science and Technology · CNTongji Hospital · CN

Funding

National Natural Science Foundation of China 81702518
6 · The paper itself

Abstract

Both cadmium (Cd) and polycyclic aromatic hydrocarbons (PAHs) are known reproductive toxicants, but their co-exposure and interaction effect on semen quality particularly in nonsmokers remain unknown. We included 333 nonsmoking men and analyzed their urine and semen samples for heavy metals and PAH metabolites. Restricted cubic spline models were used to explore the dose-response relationship between each OH-PAHs, Cd, and semen quality parameters; the generalized linear model was performed to examine the interaction of each urinary OH-PAH metabolite and Cd concentration on semen quality. Also, stratified analysis was applied to further illustrate the independent effect of PAHs on semen quality parameters in low and high concentration Cd subgroups. The dose-response and interaction effect of PAHs and Cd on male semen quality was observed. Stratified analysis in the high concentration Cd subgroup showed a negative association of 1-OHPyr concentration with semen motility. Our findings indicate that Cd not only modifies the association between PAHs and semen quality but can also exacerbate the toxic effect of pyrene on semen quality parameters. However, further studies with larger samples are needed to confirm the findings.

Indexed as

Polycyclic Aromatic HydrocarbonsSemen AnalysisCadmiumHumansMaleNon-SmokersSperm MotilityCadmiumPolycyclic Aromatic HydrocarbonsCadmiumHeavy metalInteractionMale reproductive healthPolycyclic aromatic hydrocarbonsSemen quality

Identifiers

PMID32557064
OpenAlexW3036614235

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.