ArticleJournal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract2020
Pre-operative Sarcopenia Predicts Low Islet Cell Yield Following Total Pancreatectomy with Islet Autotransplantation for Chronic Pancreatitis.
Article in Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 2 of them syntheses that pooled it.
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Who cites it
12 citing papers in PubMed, 2 syntheses or guidelines pooled it, 21 citations in OpenAlex.
- Prevalence and Risk of Sarcopenia in Patients with Chronic Pancreatitis: Systematic Review and Meta-Analysis.Nutrients · 2025Pooled it
- Perioperative Nutritional Aspects in Total Pancreatectomy: A Comprehensive Review of the Literature.Nutrients · 2021Pooled it
- Body Composition is Associated With Islet Function After Pancreatectomy and Islet Autotransplantation for Pancreatitis.The Journal of clinical endocrinology and metabolism · 2021Trial
- Article
- Malnutrition and sarcopenia are associated with poor quality of life in Indian patients with chronic pancreatitis.Indian journal of gastroenterology : official journal of the Indian Society of Gastroenterology · 2026Article
- Association of sarcopenia and pancreatic exocrine insufficiency in older adults type 2 diabetes mellitus patients.Aging clinical and experimental research · 2025Article
- Type 5 diabetes mellitus: redefining pancreatogenic diabetes through molecular, imaging, and AI-driven evidence.Frontiers in endocrinology · 2025Review
- Sarcopenia: An Assessment into the Prevalence and Disease Burden in Chronic Pancreatitis Patients.Journal of frailty, sarcopenia and falls · 2023Article
- Sarcopenia in Chronic Pancreatitis - Prevalence, Diagnosis, Mechanisms and Potential Therapies.Current gastroenterology reports · 2022Review
- Reduced bone mineral density in the first year after total pancreatectomy with islet autotransplantation (TPIAT).Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.] · 2021Article
- Total pancreatectomy sequelae and quality of life: results of islet autotransplantation as a possible mitigation strategy.Updates in surgery · 2021Review
- Prevalence and Impact of Sarcopenia in Chronic Pancreatitis: A Review of the Literature.World journal of surgery · 2021Review
Corrections and comments
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Authors and funding
13 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND AND
aimSarcopenia defined as degenerative loss of skeletal muscle mass associated with aging, represents an objective parameter to measure frailty and to estimate patient's physiologic reserves. It is a robust predictor of post-operative complications in transplantation and major oncologic surgeries. There is no data regarding the prevalence of sarcopenia in chronic pancreatitis or its impact on the outcome of patients undergoing TPIAT for CP. We sought to estimate the prevalence of sarcopenia, its impact on post-operative morbidity and prediction of islet yield and metabolic outcomes in patients undergoing TPIAT.
methodsAdult patients undergoing TPIAT between 2008 and 2018 were identified from our prospectively maintained database and were included if they had CT within 6 months before TPIAT. Skeletal muscle index (SMI) was evaluated by pre-operative CT at the level of L3 vertebra. Sarcopenia was defined as SMI < 52.4 in males and < 38.5 in females. Post-operative morbidity occurring within 90 days after TPIAT was graded as per the validated Clavien-Dindo score. Major post-surgical morbidity was defined as Clavien-Dindo score of IIIa or more. The yield of islets was quantified as islet equivalents (IEQ) and IEQ/kg recipient body weight was calculated.
resultsOne hundred and thirty-eight patients underwent TPIAT, with 46 (one-third) being classified as having pre-operative sarcopenia based on CT. No significant differences were observed in the incidence of any major surgical complications, length of hospital stay (median (range in days) 11
conclusionSarcopenia is frequent in CP patients undergoing TPIAT, but not readily recognized by standard anthropometric measurement. Sarcopenia was associated with increased chance of discharge to a residential rehabilitation facility and with a poor islet yield during TPIAT. It is therefore critical to optimize nutrition prior to TPIAT surgery in CP patients.
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