ArticleLasers in medical science2021
Improving imaging depth by dynamic laser speckle imaging and topical optical clearing for in vivo blood flow monitoring.
Article in Lasers in medical science, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed, 15 citations in OpenAlex.
- Lightweight denoising speckle contrast image GAN for real-time denoising of laser speckle imaging of blood flow.Biomedical optics express · 2025Article
- Deep learning automatically assesses 2-µm laser-induced skin damage OCT images.Lasers in medical science · 2024Article
- Review
- Article
- Evaluation of a 3.8-µm laser-induced skin injury and their repair with in vivo OCT imaging and noninvasive monitoring.Lasers in medical science · 2022Article
- Spatiotemporal absorption fluctuation imaging based on U-Net.Journal of biomedical optics · 2022Article
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Authors and funding
3 authors at 1 institution in 1 country.
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Abstract
Laser speckle contrast imaging (LSI) is a promising non-invasive full-field blood flow monitoring technique. However, it is still far from clinic practice due to insufficient contrast-to-noise ratio (CNR) and limited detection depth. In this study, an in vivo laser speckle imaging visualization system was constructed to observe the blood circulation on a dorsal skin. A dynamic laser speckle imaging (dLSI) scheme, other than traditional laser speckle contrast analysis method, was applied to separate the dynamic light scattering from the static one to increase the image CNR. Based on the theoretical optimization for dLSI, at least two pixels are required for speckle pattern sampling and a spatial window size of 7 × 7 was optimal to balance the spatial resolution and statistical accuracy. The in vivo experiment observation shows that the CNR is improved 8.4 times by dLSI. The blood vessels were more pronounced, and more capillaries can be observed than in traditional laser speckle contrast images. Topical optical clearing technique by thiazone was combined with dLSI to increase the sampling depth from 700 to 1000 μm.
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Registered trials
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