Trial reportPediatric nephrology (Berlin, Germany)2020
Corticosteroids to prevent kidney scarring in children with a febrile urinary tract infection: a randomized trial.
Trial report in Pediatric nephrology (Berlin, Germany), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01391793 (Corticosteroids for Children With Febrile Urinary Tract Infections), which is not on this map. Cited by 17 papers, 4 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Corticosteroids for Children With Febrile Urinary Tract Infections
Who cites it
17 citing papers in PubMed, 4 syntheses or guidelines pooled it, 33 citations in OpenAlex.
- Adverse Events Following Short-Course Systemic Corticosteroids Among Children and Adolescents: A Systematic Review and Meta-Analysis.JAMA network open · 2025Pooled it
- Evidence-based clinical practice guideline for management of urinary tract infection and primary vesicoureteric reflux.Pediatric nephrology (Berlin, Germany) · 2024Guideline
- The efficacy and safety of corticosteroids in pediatric kidney scar prevention after urinary tract infection: a systematic review and meta-analysis of randomized clinical trials.Pediatric nephrology (Berlin, Germany) · 2023Pooled it
- Corticosteroids to prevent renal scarring in children with pyelonephritis: a systematic review and meta-analysis.Journal of nephrology · 2023Pooled it
- Dexamethasone to prevent kidney scarring in acute pyelonephritis: a randomized clinical trial.Pediatric nephrology (Berlin, Germany) · 2022Trial
- Oral steroids for reducing kidney scarring in young children with febrile urinary tract infections: the contribution of Bayesian analysis to a randomized trial not reaching its intended sample size.Pediatric nephrology (Berlin, Germany) · 2021Trial
- Kidney involvement during the course of febrile urinary tract infection.Pediatric nephrology (Berlin, Germany) · 2025Review
- Adjuvant interventions for preventing kidney scarring in children with febrile urinary tract infection.The Cochrane database of systematic reviews · 2025Article
- Article
- Incidence of renal scarring on technetium-99 m dimercaptosuccinic acid renal scintigraphy after acute pyelonephritis, acute focal bacterial nephritis, and renal abscess.Annals of nuclear medicine · 2023Article
- Biomarkers for febrile urinary tract infection in children.Pediatric nephrology (Berlin, Germany) · 2022Article
- The role of renal contour change in the diagnosis of cortical scarring after urinary tract infection.American journal of nuclear medicine and molecular imaging · 2022Article
- Contemporary Management of Urinary Tract Infections in Children.Current treatment options in pediatrics · 2022Review
- Performance of Conventional Urine Culture Compared to 16S rRNA Gene Amplicon Sequencing in Children with Suspected Urinary Tract Infection.Microbiology spectrum · 2021Article
- Editorial with respect to "Corticosteroids to prevent kidney scarring in children with a febrile urinary tract infection-a randomized trial".Pediatric nephrology (Berlin, Germany) · 2021Article
- Handling Poor Accrual in Pediatric Trials: A Simulation Study Using a Bayesian Approach.International journal of environmental research and public health · 2021Article
- Differential Serum and Urine CRP, IP-10, and TRAIL Levels in Pediatric Urinary Tract Infection.Frontiers in pediatrics · 2021Article
Corrections and comments
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Authors and funding
20 authors at 7 institutions in 1 country.
Funding
Abstract
backgroundTo evaluate the efficacy of adjuvant systemic corticosteroids in reducing kidney scarring. A previous study suggested that use of adjuvant systemic corticosteroids reduces kidney scarring in children radiologically confirmed to have extensive pyelonephritis. Efficacy of corticosteroids for children with febrile urinary tract infection (UTI) has not been studied.
methodsChildren aged 2 months to 6 years with their first febrile UTI were randomized to corticosteroids or placebo for 3 days (both arms received antimicrobial therapy); kidney scarring was assessed using
resultsWe randomized 546 children of which 385 had a UTI and 254 had outcome kidney scans (instead of the 320 planned). Rates of kidney scarring were 9.8% (12/123) and 16.8% (22/131) in the corticosteroid and placebo groups, respectively (p = 0.16), corresponding to an absolute risk reduction of 5.9% (95% confidence interval: - 2.2, 14.1).
conclusionWhile children randomized to adjuvant corticosteroids tended to develop fewer kidney scars than children who were randomized to receive placebo, a statistically significant difference was not achieved. However, the study was limited by not reaching its intended sample size. CLINICAL
trial registrationClinicaltrials.gov , NCT01391793, Registered 7/12/2011 Graphical abstract.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.