Evidence map›Paper›PMID 32556928›Full record

ArticleMetabolic brain disease2020

β-Asarone improves learning and memory in Aβ

Yufeng Han, Nanbu Wang, Jian Kang, Yongqi Fang

Abstract read
PubMed Publisher
In one paragraph

Article in Metabolic brain disease, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
40citing papers in PubMed, 2 pooled it
4.5field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

40 citing papers in PubMed, 2 syntheses or guidelines pooled it, 66 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Review
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  10. Mitochondrial dysfunction in Alzheimer's disease: Guiding the path to targeted therapies.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2025
    Review
  11. Review
  12. Volatile oil ofFrontiers in pharmacology · 2025
    Review
  13. Review
  14. New Value ofNutrients · 2024
    Article
  15. Article
  16. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Yufeng HanGuangzhou University of Traditional Chinese Medicine First Affiliated Hospital, Guangzhou, China.
Nanbu WangGuangzhou University of Traditional Chinese Medicine First Affiliated Hospital, Guangzhou, China.
Jian KangGuangzhou University of Traditional Chinese Medicine First Affiliated Hospital, Guangzhou, China.
Yongqi FangGuangzhou University of Traditional Chinese Medicine First Affiliated Hospital, Guangzhou, China. fangyq2@163.com.
First Affiliated Hospital of Guangzhou University of Chinese Medicine · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Alzheimer's disease (AD) is a chronic neurodegenerative disease that is characterized by the extracellular accumulation of β-amyloid (Aβ). Many studies have shown a close relationship between autophagy and the formation of Aβ. As AD develops and progresses, mitophagy diminishes insoluble Aβ, and mitochondrial dysfunction seems to be a determining factor in the pathogenesis of AD. In our previous study, we showed that β-asarone pharmacological effects in APP/PS1 transgenic mice, reducing Aβ expression. However, the specific mechanism of this effect remains unclear. In this study, AD model rats induced by intracerebroventricular injection of Aβ

Indexed as

Allylbenzene DerivativesAlzheimer DiseaseAmyloid beta-PeptidesAnimalsAnisolesDisease Models, AnimalFemaleHippocampusLearningMaleMaze LearningMemoryMitophagyNeuronsPeptide FragmentsProtein KinasesAllylbenzene DerivativesAmyloid beta-Peptidesamyloid beta-protein (1-42)Anisolesasaroneparkin proteinPeptide FragmentsProtein KinasesPTEN-Induced Putative KinaseUbiquitin-Protein LigasesAlzheimer’s diseaseMitophagyPINK1/Parkinβ-Asarone

Identifiers

PMID32556928
OpenAlexW3036909670

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.