ArticleNeurocritical care2021
Assessment of Dynamic Intracranial Compliance in Children with Severe Traumatic Brain Injury: Proof-of-Concept.
Article in Neurocritical care, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
10 citing papers in PubMed, 16 citations in OpenAlex.
- Effect of caudal block injection speed on optic nerve sheath diameter in pediatric surgeries: A prospective observational cohort study.Medicine · 2026Observational
- Pupillomotor Dysfunction and Outcomes After Decompressive Craniectomy in Pediatric Patients.Journal of clinical medicine · 2026Article
- Continuous monitoring of intracranial pressure and end tidal carbon dioxide variations in traumatic brain injury: introducing the carbon dioxide reactivity index (CO2Rx).Journal of clinical monitoring and computing · 2025Observational
- Impaired Cerebral Autoregulation in Children.Pediatric neurology · 2025Review
- Predictive Values for Time from Transducer Stopcock Closure to Accurate Intracranial Pressure Reading.Neurocritical care · 2023Article
- Multimodal Neurologic Monitoring in Children With Acute Brain Injury.Pediatric neurology · 2022Review
- Obesity and its implications on cerebral circulation and intracranial compliance in severe COVID-19.Obesity science & practice · 2021Article
- Increase in Brain Volume After Aneurysmal Subarachnoid Hemorrhage Leads to Unfavorable Outcome: A Retrospective Study Quantified by CT Scan.Frontiers in neurology · 2021Article
- "Take a Number"-Precision Monitoring Directs Precision Therapy.Neurocritical care · 2020Article
- Cerebrospinal fluid dysregulation and post-traumatic hydrocephalus after paediatric traumatic brain injury.Frontiers in neurologyReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 1 institution in 1 country.
Funding
Abstract
BACKGROUND AND
aimsIntracranial compliance refers to the relationship between a change in intracranial volume and the resultant change in intracranial pressure (ICP). Measurement of compliance is useful in managing cardiovascular and respiratory failure; however, there are no contemporary means to assess intracranial compliance. Knowledge of intracranial compliance could complement ICP and cerebral perfusion pressure (CPP) monitoring in patients with severe traumatic brain injury (TBI) and may enable a proactive approach to ICP management. In this proof-of-concept study, we aimed to capitalize on the physiologic principles of intracranial compliance and vascular reactivity to CO
methodsContinuous ICP and end-tidal CO
resultsA total of 978 h of ICP and ETCO
conclusionsIndirect assessment of dynamic intracranial compliance in TBI patients using standard-of-care monitoring appears feasible and suggests a prolonged period of derangement out to 5 days post-injury. Further study is ongoing to determine if the PCI-a new physiologic index, complements utility of ICP and/or CPP in guiding management of patients with severe TBI.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.