Evidence map›Paper›PMID 32556832›Full record

ReviewNeurosurgical review2021

Tranexamic acid in Neurosurgery: a controversy indication-review.

José Luiz de Faria, Josué da Silva Brito, Louise Teixeira Costa E Silva, Christiano Tadeu Sanches Mattos Kilesse, Nicolli Bellotti de Souza, Carlos Umberto Pereira, Eberval Gadelha Figueiredo, Nícollas Nunes Rabelo

Abstract readReview
PubMed Publisher
In one paragraph

Review in Neurosurgical review, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed, 5 pooled it
3.1field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 5 syntheses or guidelines pooled it, 40 citations in OpenAlex.

  1. Therapeutic efficacy of tranexamic acid on traumatic brain injury: a systematic review and meta-analysis.Scandinavian journal of trauma, resuscitation and emergency medicine · 2024
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  11. Anaesthesia Considerations on Paediatric Neurosurgery.Turkish journal of anaesthesiology and reanimation · 2025
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  19. Delayed hemorrhage after pediatric stereo-electroencephalography: delayed occurrence or delayed diagnosis?Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2021
    Article
  20. A Systematic Review of Tranexamic Acid in Plastic Surgery: What's New?Plastic and reconstructive surgery. Global open · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

José Luiz de FariaDepartment of Neurosurgery, University Center UNiAtenas, Paracatu, Minas Gerais, Brazil.ORCID http://orcid.org/0000-0001-6094-0246
Josué da Silva BritoDepartment of Neurosurgery, University Center UNiAtenas, Paracatu, Minas Gerais, Brazil.ORCID https://orcid.org/0000-0003-2142-3689
Louise Teixeira Costa E SilvaDepartment of Neurosurgery, University Center UNiAtenas, Paracatu, Minas Gerais, Brazil.ORCID https://orcid.org/0000-0002-3770-9430
Christiano Tadeu Sanches Mattos KilesseDepartment of Neurosurgery, University Center UNiAtenas, Paracatu, Minas Gerais, Brazil.ORCID https://orcid.org/0000-0003-2213-0570
Nicolli Bellotti de SouzaDepartment of Neurosurgery, University Center UNiAtenas, Paracatu, Minas Gerais, Brazil.ORCID https://orcid.org/0000-0001-8440-1482
Carlos Umberto PereiraDepartment of Neurosurgery of FBHC and Neurosurgery Service, Aracaju, Sergipe, Brazil.
Eberval Gadelha FigueiredoDepartment of Neurosurgery, Hospital das Clinicas da Faculdade de Medicina, University of Sao Paulo, Sao Paulo, Brazil.ORCID https://orcid.org/0000-0001-9094-6622
Nícollas Nunes RabeloDepartment of Neurosurgery, University Center UNiAtenas, Paracatu, Minas Gerais, Brazil. nicollasrabelo@hotmail.com.ORCID https://orcid.org/0000-0001-5238-8658
Universidade do Estado de Minas Gerais · BRCentro Universitário das Faculdades Metropolitanas Unidas · BRHospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Tranexamic acid (TXA) is one of the measures indicated to reduce bleeding and the need for volume replacement. However, data on risks and benefits are controversial. This study analyzes the effectivity and risks of using tranexamic acid in neurosurgery. We selected articles, published from 1976 to 2019, on the PubMed, EMBASE, Science Direct, and The Cochrane Database using the descriptors: "tranexamic acid," "neurosurgery," "traumatic brain injury," "subdural hemorrhage," "brain aneurysm," and "subarachnoid hemorrhage." TXA can reduce blood loss and the need for blood transfusion in trauma and spinal surgery. Despite the benefits of TXA, moderate-to-high doses are potentially associated with neurological complications (seizures, transient ischemic attack, delirium) in adults and children. In a ruptured intracranial aneurysm, the use of TXA can considerably reduce the risk of rebleeding, but there is weak evidence regarding its influence on mortality reduction. The TXA use in brain surgery does not present benefit. However, this conclusion is limited because there are few studies. TXA in neurosurgeries is a promising method for the maintenance of hemostasis in affected patients, mainly in traumatic brain injury and spinal surgery; nevertheless, there is lack of evidence in brain and vascular surgeries. Many questions remain unanswered, such as how to determine the dosage that triggers the onset of associated complications, or how to adjust the dose for chronic kidney disease patients.

Indexed as

AdultAntifibrinolytic AgentsBlood Loss, SurgicalBlood TransfusionBrain Injuries, TraumaticChildHemorrhageHumansMeta-Analysis as TopicNeurosurgical ProceduresRandomized Controlled Trials as TopicRetrospective StudiesSeizuresTranexamic AcidAntifibrinolytic AgentsTranexamic AcidAntifibrinolyticBlood loss surgicalBrain injuriesNeurosurgeryTranexamic acid

Identifiers

PMID32556832
OpenAlexW3036556465

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.