Evidence map›Paper›PMID 32556798›Full record

ArticlePharmaceutical research2020

Improving Tabletability of Excipients by Metal-Organic Framework-Based Cocrystallization: a Study of Mannitol and CaCl

Hao Cheng, Yuanfeng Wei, Shiru Wang, Qiyang Qiao, Weili Heng, Linghe Zhang, Jianjun Zhang, Yuan Gao, Shuai Qian

Abstract readComparative Study
PubMed Publisher
In one paragraph

Article in Pharmaceutical research, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
2.7field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 22 citations in OpenAlex.

  1. Review
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 2 countries.

Hao ChengSchool of Traditional Chinese Pharmacy, China Pharmaceutical University, Nanjing, 211198, People's Republic of China.
Yuanfeng WeiSchool of Traditional Chinese Pharmacy, China Pharmaceutical University, Nanjing, 211198, People's Republic of China.
Shiru WangSchool of Traditional Chinese Pharmacy, China Pharmaceutical University, Nanjing, 211198, People's Republic of China.
Qiyang QiaoSchool of Pharmacy, China Pharmaceutical University, Nanjing, 211198, People's Republic of China.
Weili HengSchool of Pharmacy, China Pharmaceutical University, Nanjing, 211198, People's Republic of China.
Linghe ZhangDepartment of Chemistry, Smith College, Northampton, MA, 01063, USA.
Jianjun ZhangSchool of Pharmacy, China Pharmaceutical University, Nanjing, 211198, People's Republic of China. amicute@163.com.
Yuan GaoSchool of Traditional Chinese Pharmacy, China Pharmaceutical University, Nanjing, 211198, People's Republic of China. newgaoyuan@163.com.
Shuai QianSchool of Traditional Chinese Pharmacy, China Pharmaceutical University, Nanjing, 211198, People's Republic of China. silence_qs@163.com.ORCID http://orcid.org/0000-0003-1961-4128
China Pharmaceutical University · CNSmith College · US

Funding

"Double First-Class" University Project CPU2018GY11"Double First-Class" University Project CPU2018GY27National Natural Science Foundation of China 81703712National Natural Science Foundation of China 81773675National Natural Science Foundation of China 81873012
6 · The paper itself

Abstract

purposeTo improve tabletability of pharmaceutical excipient mannitol by forming cocrystal with metal-organic framework (MOF) structure.

methodsMannitol was cocrystallized with CaCl

resultsThe prepared cocrystal contains mannitol, CaCl

conclusionsMOF-based cocrystallization will be a promising and valuable approach to tailor mechanical properties of pharmaceutical materials in order to achieve better pharmaceutical performance.

Indexed as

Calcium ChlorideCompressive StrengthCrystallizationDrug CompoundingExcipientsMannitolMolecular StructureTabletsTensile StrengthCalcium ChlorideExcipientsMannitolTabletsbonding strengthcocrystalMannitolMOFtabletability

Identifiers

PMID32556798
OpenAlexW3036576932

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.