Trial reportSurgical endoscopy2021
A prospective randomized controlled trial of omeprazole for preventing esophageal stricture in grade 2b and 3a corrosive esophageal injuries.
Trial report in Surgical endoscopy, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
8 citing papers in PubMed, 1 synthesis or guideline pooled it, 17 citations in OpenAlex.
- Short-term and long-term management of caustic-induced gastrointestinal injury: An evidence-based practice guidelines.Indian journal of gastroenterology : official journal of the Indian Society of Gastroenterology · 2025Guideline
- Esophagogastroduodenoscopy Versus Thoracic Computed Tomography in Prediction of Caustic Stricture.Digestive diseases and sciences · 2026Article
- Endoscopic puncture and recanalization in a child with corrosive esophageal stenosis and atresia: case report and literature review.BMC pediatrics · 2026Review
- Post-Caustic Esophagitis: Updated Clinical Insights and Practical Lessons from Case Illustrations.Journal of clinical medicine · 2025Review
- Endoscopic treatment of extreme esophageal stenosis complicated with esophagotracheal fistula: A case report.World journal of gastrointestinal surgery · 2024Article
- Endoscopic dilation with bougies versus balloons in caustic esophageal strictures: 17-year experience from a tertiary care center.Surgical endoscopy · 2023Article
- Endoscopic Evaluation for Stricture Formation Post Button Battery Ingestion.Pediatric reports · 2021Article
- The Effect of the COVID-19 on Corrosive Ingestion in Thailand.Open access emergency medicine : OAEM · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesEsophageal stricture is a significant complication of grade 2b and 3a esophageal injuries and causes much patient suffering. Preventing strictures would be beneficial to patients but there are currently no proven effective drugs. This study aimed to evaluate the effect of omeprazole for preventing esophageal stricture in adults with grade 2b and 3a corrosive esophageal injuries.
methodsThis study was an open single-center prospective randomized controlled trial that took place from April 2018 to January 2020. Patients were randomized to standard treatment or 80 mg/day intravenously × 3 days followed by 40 mg/day orally for 4 weeks. They were endoscoped at baseline and 4 weeks post discharge. Strictures were confirmed radiologically.
results20 patients were enrolled: 15 with grade 2b and five with grade 3a injuries. Standard care and omeprazole groups numbered 10 each. At 1 month, seven and two patients developed strictures in the standard and omeprazole groups, respectively, p = 0.024, for a risk reduction of 71.4%.
conclusionsOmeprazole reduced the risk of short-term developing esophageal strictures following grade 2b and 3a corrosive esophageal injuries. Larger studies are needed to reconfirm this finding. Thai Clinical Trials Registry (TCTR) number TCTR20190504001.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.