ArticleInternational ophthalmology2020
Posterior pole retinal thickness distribution pattern in keratoconus.
Article in International ophthalmology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed.
- Structural retinal and choroidal changes in keratoconus: A cross-sectional OCT study stratified by ABCD grading.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2026Observational
- Corneal Higher-Order Aberrations and Posterior Segment Changes in Keratoconus: A Multimodal OCT and OCTA Study.Diagnostics (Basel, Switzerland) · 2026Article
- Retinal thickness and vascular density changes in Keratoconus: A systematic review and meta-analysis.Heliyon · 2025Article
- Assessment of OCT and Angio-OCT Parameters in Keratoconus Patients with and without Penetrating Keratoplasty.Journal of clinical medicine · 2024Article
- Reduced Retinal Blood Vessel Densities Measured by Optical Coherence Tomography Angiography in Keratoconus Patients Are Negatively Correlated with Keratoconus Severity.Diagnostics (Basel, Switzerland) · 2024Article
- Deep learning prediction of steep and flat corneal curvature using fundus photography in post-COVID telemedicine era.Medical & biological engineering & computing · 2024Article
- Posterior segment alterations in keratoconus patients: an updated comprehensive review.Therapeutic advances in ophthalmologyReview
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Authors and funding
6 authors.
Funding
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Abstract
purposeTo evaluate the pattern of retinal thickness distribution in patients with keratoconus (KCN) and its correlation with disease severity.
methodsFor this cross-sectional cohort study, the study subjects with documented keratoconus and normal eyes were prospectively enrolled. All subjects had anterior segment (Pentacam HR) and posterior segment (Spectralis) imaging. Posterior segment imaging by optical coherence tomography included the posterior pole asymmetry analysis map. Data were analyzed with multiple linear regression models and correlation tests to examine the mean and variance of the measured thickness of the retina and its distribution relative to the presence and severity of KCN.
resultsA total of 24 subjects with keratoconus (48 eyes) and 14 normal subjects (28 eyes) enrolled in this study. The posterior pole retinal thickness, both superior and inferior hemifields, as well as the overall retinal thickness in KCN patients was greater than the control group. There was a direct correlation between the overall retinal thickness of the posterior pole and the severity of KCN (R
conclusionAlthough KCN is a disease of the anterior segment of the eye, we found an orderly increase in posterior pole retinal thickness that is correlated with the severity of disease in KCN eyes compared to control. These findings suggest that the retina may maintain some degree of plasticity to respond to the degraded optical system of the eye.
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