ArticleClinical oral investigations2021
Efficacy of Er,Cr:YSGG laser-assisted delivery of topical anesthesia in the oral mucosa.
Article in Clinical oral investigations, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07169032 (The Effect of Er,Cr), which is not on this map. Cited by 3 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
The Effect of Er,Cr:YSGG Laser-assisted Topical Anesthetic on Oral Mucosal Anesthesia
Who cites it
3 citing papers in PubMed, 7 citations in OpenAlex.
- A Comparative Evaluation of the Effect of Photobiomodulation on the Depth of Anaesthesia During Endodontic Treatment of Teeth with Symptomatic Irreversible Pulpitis-A Prospective Clinical Trial.Journal of pharmacy & bioallied sciences · 2025Article
- Advanced Lasers and Their Applications in Dentistry.Dentistry journal · 2025Review
- Evaluating the Efficacy of the Er,Cr:YSGG Fractional Laser Before Treatment With Triamcinolone NN Ointment in Oral Lichen Planus Lesions.Journal of lasers in medical sciences · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveLasers which can reduce epithelium thickness will enhance the penetration of topical drugs. To date, no study has assessed the efficacy of this technique in the oral mucosa. The aim of this study was the evaluation of efficacy of this technique in increasing the effect of topical anesthesia in the oral mucosa. MATERIALS AND
methodsOn 20 volunteers, half of the lower lip mucosa was irradiated with Er,Cr:YSGG laser with 2780 nm wavelength and 1.3 J/cm
resultsThe mean depth of anesthesia at the control side was 6.95 ± 2.43, 8.45 ± 4.05, 6.5 ± 3.00, and 3.85 ± 2.08 mm at 5, 20, 35, and 60 min, respectively. These values at the test side were 12.25 ± 5.42, 13.25 ± 5.02, 11.4 ± 5.03, and 9.10 ± 5.84 mm, respectively. According to repeated-measures ANOVA, the effect of the type of the treatment on the depth of insertion was significant (P < 0.001).
conclusionsThe results showed that irradiation of Er,Cr:YSGG laser before the topical application of the anesthetic agents on the oral mucosa increases their efficacy. CLINICAL RELEVANCE: Topical anesthesia is used to enhance dental procedures painlessly, but there is controversy in their efficacy. Laser-assisted drug delivery to the oral mucosa can enhance their efficacy.
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