ArticleClinical oral investigations2021
Usefulness of hemoglobin examination in gingival crevicular fluid during supportive periodontal therapy to diagnose the pre-symptomatic state in periodontal disease.
Article in Clinical oral investigations, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 13 citations in OpenAlex.
- Evaluation of inflammatory periodontal tissue by detecting the hemoglobin released in gingival crevicular fluid during supportive periodontal therapy.Odontology · 2026Article
- Colouring dysbiosis: FetB-dependent Mn-PPIX produced by Porphyromonas gingivalis shapes the oral microbiota.NPJ biofilms and microbiomes · 2026Article
- The survival status ofJournal of oral microbiology · 2026Review
- Development of a novel method to evaluate gingivitis in children by combining rapid saliva test systems.Scientific reports · 2025Article
- Exploring heme and iron acquisition strategies of Porphyromonas gingivalis-current facts and hypotheses.FEMS microbiology reviews · 2025Review
- Comparison of three fluids for calibration of the new Periotron® 8010.Medicina oral, patologia oral y cirugia bucal · 2023Article
- The Chairside Periodontal Diagnostic Toolkit: Past, Present, and Future.Diagnostics (Basel, Switzerland) · 2021Review
- Predictive Periodontitis: The Most Promising Salivary Biomarkers for Early Diagnosis of Periodontitis.Journal of clinical medicine · 2021Review
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
objectivesThe absence of bleeding on probing (BOP) is a good predictor of disease stability. This study investigated whether detection of hemoglobin (Hb) in gingival crevicular fluid (GCF) indicates minute signs of periodontal disease, even in BOP (-) cases. MATERIALS AND
methodsGCF was collected from gingival sulci of 152 sound maxillary and mandibular teeth from 76 patients who had entered supportive periodontal therapy (SPT) using the split-mouth design. As clinical parameters, plaque index, GCF amount, gingival index, probing depth (PD), clinical attachment level, BOP, and alveolar bone resorption ratio were then recorded. As biochemical parameters, Hb amount, alkaline phosphatase (ALP) activity, and protein amount in GCF were measured. Periodontal conditions of diseased sites (PD ≥ 4 mm, BOP (+)) and healthy sites (PD ≤ 4 mm, BOP (-)) were further classified into two groups using the Hb cutoff value determined by PD and BOP and analyzed.
resultsDespite being healthy, ALP activity and protein amount in sulci of the group with Hb level greater than the cutoff value were significantly higher than those in the group with Hb level less than the cutoff value (P < 0.01).
conclusionsThis study indicates that Hb examination is a promising candidate marker of pre-symptomatic periodontal disease because Hb presence in GCF suggests slight tissue damage, even in healthy sites defined as BOP (-). CLINICAL RELEVANCE: Hb examination of GCF is a powerful diagnostic tool for pre-symptomatic diagnosis of periodontal disease.
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