Evidence map›Paper›PMID 32556622›Full record

SynthesisSupportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer2020

A systematic review of the impact of contemporary treatment modalities for cervical cancer on women's self-reported health-related quality of life.

L M Wiltink, M King, F Müller, M S Sousa, M Tang, A Pendlebury, J Pittman, N Roberts, L Mileshkin, R Mercieca-Bebber and 3 more

Abstract readSystematic Review
PubMed Publisher
In one paragraph

Synthesis in Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Trial
  4. Article
  5. Article
  6. Vaginal morbidity, sexual functioning, and health-related quality of life in cervical cancer survivors: a cross-sectional multicenter study (VAMOS).Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2023
    Article
  7. Article
  8. Impact of Cervical Cancer on Quality of Life and Sexuality in Female Survivors.International journal of environmental research and public health · 2023
    Article
  9. Article
  10. Postoperative health-related quality of life of patients with gynecological malignancy: a meta-analysis.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2021
    Review
  11. Review
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

L M WiltinkThe University of Sydney, Faculty of Science, School of Psychology, Quality of Life Office, Sydney, Australia. l.m.wiltink@lumc.nl.ORCID https://orcid.org/0000-0003-3483-4241
M KingThe University of Sydney, Faculty of Science, School of Psychology, Quality of Life Office, Sydney, Australia.
F MüllerThe University of Sydney, Faculty of Science, School of Psychology, Quality of Life Office, Sydney, Australia.
M S SousaFaculty of Health, IMPACCT, University of Technology Sydney, Sydney, Australia.
M TangCentre for Big Data Research in Health, University of New South Wales, Sydney, Australia.
A PendleburyDepartment of Oncology, Mercy Hospital for Women, Heidelberg, Australia.
J PittmanBlacktown Hospital, Western Sydney Local Health District, Sydney, Australia.
N RobertsCancer Care Services, Royal Brisbane and Women's Hospital, Brisbane, Australia.
L MileshkinDepartment of Medical Oncology, Peter MacCallum Cancer Centre, Melbourne, Australia.
R Mercieca-BebberUniversity of Sydney, NHMRC Clinical Trials Centre, Sydney, Australia.
M-A TaitThe University of Sydney, Faculty of Science, School of Psychology, Quality of Life Office, Sydney, Australia.
R CampbellThe University of Sydney, Faculty of Science, School of Psychology, Quality of Life Office, Sydney, Australia.
C RutherfordThe University of Sydney, Faculty of Science, School of Psychology, Quality of Life Office, Sydney, Australia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeGiven the high survival rate of cervical cancer patients, understanding women's health-related quality of life (HRQL) during and after treatment is of major clinical importance. We conducted a systematic review to synthesize all available evidence about the effects of each contemporary treatment modality for cervical cancer on all dimensions of women's HRQL, including symptoms, functioning, and global HRQL.

methodsWe searched four electronic databases from January 2000 to September 2019, cross-referenced and searched by author name for studies of patients treated for cervical cancer that reported patient-reported outcomes (PROs) before treatment and with at least one post-treatment measurement. Two independent reviewers applied inclusion and quality criteria and extracted findings. Studies were categorized by treatment to determine specific treatment effects on PROs. Results were narratively summarized.

resultsWe found twenty-nine papers reporting 23 studies. After treatments with curative intent for early or locally advanced disease, lymphedema, diarrhea, menopausal symptoms, tight and shorter vagina, pain during intercourse, and sexual worries remained long-term problems; however, sexual activity improved over time. HRQL and psychological distress were impacted during treatment with also worsening of global HRQL but improved 3-6 months after treatment. In patients with metastatic or recurrent disease, pain improved during palliative treatment or remained stable, with no differences in global HRQL found over time.

conclusionWhereas most symptoms worsen during treatment and improve in the first 3 months after completing treatment, symptoms like lymphedema, menopausal symptoms, and sexual worries develop gradually and persist after curative treatment. These findings can be used to inform clinical practice and facilitate communication and shared decision-making. More research is needed in very early cervical cancer and the impact of fertility sparing therapy on PROs.

Indexed as

Patient Reported Outcome MeasuresFemaleHumansQuality of LifeSelf ReportUterine Cervical NeoplasmsCervical cancerChemotherapyPatient-reported outcomesQuality of lifeRadiotherapySurgery

Identifiers

PMID32556622

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.