ArticlePediatric radiology2020
Validation of threshold values for pancreas thickness and T1-weighted signal intensity ratio in the pediatric pancreas.
Article in Pediatric radiology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed.
- T1 signal intensity ratio variability based on sampling strategies in the pancreas of children and young adults.Abdominal radiology (New York) · 2025Article
- T1 signal intensity ratio correlation with T1 mapping in pediatric pancreatitis.Abdominal radiology (New York) · 2025Article
- Practical approach to quantitative liver and pancreas MRI in children.Pediatric radiology · 2025Review
- Body MRI in pediatrics: where we are and what the future holds.Pediatric radiology · 2025Review
- Current and emerging artificial intelligence applications for pediatric abdominal imaging.Pediatric radiology · 2022Review
- Magnetic resonance imaging glossary of findings of pediatric pancreatitis and the revised Atlanta classification.Pediatric radiology · 2022Review
- Current State of Imaging of Pediatric Pancreatitis:AJR. American journal of roentgenology · 2021Review
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Authors and funding
6 authors.
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Abstract
backgroundPancreas atrophy and the loss of T1-weighted signal intensity by magnetic resonance imaging (MRI) are findings of chronic pancreatitis.
objectiveThe purpose of this study was to test published normal values and cutoffs for pancreas thickness and the pancreas:spleen T1-weighted signal intensity ratio in children without pancreatic disease. MATERIALS AND
methodsThis was a secondary analysis of prospectively collected MRI data for 50 children (range: 6.3-15.9 years; 27 female) with no history of pancreatic disease. Two observers (R1, R2) measured linear pancreas thickness on axial T1-weighted, fat-saturated gradient recalled echo images and placed regions of interest in the pancreas and spleen to calculate the T1-weighted signal intensity ratio. Measurements were compared to published pediatric normal values (computed tomography [CT], ultrasound [US]) and adult cutoffs (CT, MRI).
resultsCompared to published pediatric values for CT, 68% (R1: 34/50) or 40% (R2: 22/50) of participants had ≥1 pancreas segment with thickness below the normal range. No participant had a thickness value below the normal range published for US. Compared to cutoff values in adults, 84% (R1: 42/50) or 80% (R2: 40/50) of participants met the criteria for pancreas atrophy. Mean T1-weighted signal intensity ratio was 1.33±0.15 (R1) and 1.32±0.16 (R2). Twelve (R1: 24.5% of 49) or 11/49 (R2: 22.4%) participants had a T1-weighted signal intensity ratio below the threshold associated with exocrine insufficiency in adults.
conclusionPreviously defined thresholds for pancreas thickness and pancreas:spleen T1-weighted signal intensity ratio appear too restrictive for a pediatric population. Further study is needed to define optimal quantitative metrics for findings of chronic pancreatitis in children.
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