Evidence map›Paper›PMID 32556433›Full record

ArticleKnee surgery, sports traumatology, arthroscopy : official journal of the ESSKA2021

Bone marrow aspirate concentration provided better results in cartilage regeneration to microfracture in knee of osteoarthritic patients.

Quan-He Jin, Young-Woo Chung, Seung-Min Na, Hyeon-Wook Ahn, Dong-Min Jung, Jong-Keun Seon

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Article in Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed, 1 pooled it
3.3field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 1 synthesis or guideline pooled it, 35 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Quan-He Jin *Center for Joint Disease, Chonnam National University Hospital, 42, Jebong-ro, Dong-gu, Gwangju, Republic of Korea.
Young-Woo Chung *Department of Orthopedic Surgery, Gwangju Veterans Hospital, Gwangju, Republic of Korea.
Seung-Min NaCenter for Joint Disease, Chonnam National University Hospital, 42, Jebong-ro, Dong-gu, Gwangju, Republic of Korea.
Hyeon-Wook AhnCenter for Joint Disease, Chonnam National University Hospital, 42, Jebong-ro, Dong-gu, Gwangju, Republic of Korea.
Dong-Min JungCenter for Joint Disease, Chonnam National University Hospital, 42, Jebong-ro, Dong-gu, Gwangju, Republic of Korea.
Jong-Keun SeonCenter for Joint Disease, Chonnam National University Hospital, 42, Jebong-ro, Dong-gu, Gwangju, Republic of Korea. seonbell@jnu.ac.kr.
Chonnam National University Hospital · KRVeterans Health Service Medical Center · KR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeTo determine whether microfracture with bone marrow aspirate concentrate (BMAC) improves functional outcome and cartilage regeneration better than microfracture alone in patients undergoing high tibial osteotomy (HTO) for medial unicompartmental osteoarthritis (OA).

methodsAmong 436 patients treated with HTO for medial unicompartmental OA with varus deformity between 2010 and 2016, clinical outcomes were retrospectively compared between the microfracture alone group (group I, 43 cases) and microfracture with BMAC augmentation group (group II, 48 cases). Of these, 64 patients underwent a second-look arthroscopic assessment. Clinical outcomes were compared based on the Knee Society Score (KSS), International Knee Documentation Committee (IKDC) subjective score, and Western Ontario and McMaster Universities Arthritis Index (WOMAC). Cartilage regeneration was assessed according to Koshino's staging system and the International Cartilage Repair Society (ICRS) Cartilage Repair Assessment (CRA) grading system.

resultsAt the last follow-up, there were no significant intergroup differences in terms of KSS for pain and function (p > 0.05). Moreover, WOMAC scores were similar between the two groups (p > 0.05). Regarding second-look arthroscopy findings, according to Koshino's staging system, there was no significant intergroup difference in terms of defect coverage (p = 0.187). However, group II showed a significantly better mean CRA score than group I (p = 0.035).

conclusionThere were no significant differences in clinical outcomes and cartilage regeneration between the groups. However, the CRA score was significantly higher with BMAC augmentation and microfracture than microfracture alone. Therefore, BMAC augmentation had a synergistic effect for a better cartilage regeneration, although studies with a longer follow-up might help to confirm whether microfracture with BMAC augmentation would ensure better clinical outcomes than microfracture alone for the treatment of knee OA.

Indexed as

AdultAgedArthroscopyBone Marrow CellsBone Marrow TransplantationCartilage, ArticularFemaleFractures, StressHumansKnee InjuriesMaleMiddle AgedOsteoarthritis, KneeOsteotomyRegenerationRetrospective StudiesBone marrow aspirate concentrateCartilageCartilage regenerationHigh tibial osteotomyMicrofracture

Identifiers

PMID32556433
OpenAlexW3036832385

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.