Evidence map›Paper›PMID 32556401›Full record

ArticlePsychopharmacology2020

Oleoyl alanine (HU595): a stable monomethylated oleoyl glycine interferes with acute naloxone precipitated morphine withdrawal in male rats.

Samantha M Ayoub, Reem Smoum, Mathew Farag, Harkirat Atwal, Stephen A Collins, Erin M Rock, Cheryl L Limebeer, Fabiana Piscitelli, Fabio Arturo Iannotti, Aron H Lichtman and 4 more

Abstract read
PubMed Publisher
In one paragraph

Article in Psychopharmacology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
2.3field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 21 citations in OpenAlex.

  1. Chemical Probes for Investigating the Endocannabinoid System.Current topics in behavioral neurosciences · 2026
    Review
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  13. Frontiers in synaptic neuroscience · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 4 institutions in 3 countries.

Samantha M AyoubDepartment of Psychology and Collaborative Neuroscience Program, University of Guelph, Guelph, ON, N1G 2W1, Canada.
Reem SmoumInstitute of Drug Research, Medical Faculty, Hebrew University of Jerusalem, Jerusalem, Israel.
Mathew FaragDepartment of Psychology and Collaborative Neuroscience Program, University of Guelph, Guelph, ON, N1G 2W1, Canada.
Harkirat AtwalDepartment of Psychology and Collaborative Neuroscience Program, University of Guelph, Guelph, ON, N1G 2W1, Canada.
Stephen A CollinsDepartment of Psychology and Collaborative Neuroscience Program, University of Guelph, Guelph, ON, N1G 2W1, Canada.
Erin M RockDepartment of Psychology and Collaborative Neuroscience Program, University of Guelph, Guelph, ON, N1G 2W1, Canada.
Cheryl L LimebeerDepartment of Psychology and Collaborative Neuroscience Program, University of Guelph, Guelph, ON, N1G 2W1, Canada.
Fabiana PiscitelliInstitute of Biomolecular Chemistry, Endocannabinoid Research Group, Consiglio Nazionale delle Ricerche, Pozzuoli, Naples, Italy.
Fabio Arturo IannottiInstitute of Biomolecular Chemistry, Endocannabinoid Research Group, Consiglio Nazionale delle Ricerche, Pozzuoli, Naples, Italy.
Aron H LichtmanDepartment of Pharmacology and Toxicology, Medical College of Virginia Campus, Virginia Commonwealth University, Richmond, VA, USA.
Francesco LeriDepartment of Psychology and Collaborative Neuroscience Program, University of Guelph, Guelph, ON, N1G 2W1, Canada.
Vincenzo Di MarzoInstitute of Biomolecular Chemistry, Endocannabinoid Research Group, Consiglio Nazionale delle Ricerche, Pozzuoli, Naples, Italy.
Raphael MechoulamInstitute of Drug Research, Medical Faculty, Hebrew University of Jerusalem, Jerusalem, Israel.
Linda A ParkerDepartment of Psychology and Collaborative Neuroscience Program, University of Guelph, Guelph, ON, N1G 2W1, Canada. parkerl@uoguelph.ca.ORCID http://orcid.org/0000-0002-3494-9754
University of Guelph · CAHebrew University of Jerusalem · ILUniversité Laval · CAVirginia Commonwealth University Medical Center · US

Funding

Natural Sciences and Engineering Research Council of Canada 03629
6 · The paper itself

Abstract

rationaleOleoyl glycine, a little studied fatty acid amide similar in structure to anandamide, interferes with nicotine addiction in mice and acute naloxone-precipitated morphine withdrawal (MWD) in rats. Because endogenous oleoyl glycine is subject to rapid enzymatic deactivation, we evaluated the potential of more stable analogs to interfere with opiate withdrawal.

objectivesThe potential of monomethylated oleoyl glycine (oleoyl alanine, HU595) to interfere with somatic and aversive effects of acute naloxone-precipitated MWD, its duration, and mechanism of action was assessed in male Sprague Dawley rats. The potential of dimethylated oleoyl glycine (HU596) to interfere with the aversive effects of naloxone-precipitated MWD was also investigated.

resultsOleoyl alanine (HU595) interfered with somatic and aversive effects produced by naloxone-precipitated MWD at equivalent doses (1 and 5 mg/kg, i.p.) as we have reported for oleoyl glycine; however, oleoyl alanine produced a longer lasting (60 min) interference, yet did not produce rewarding or aversive effects on its own and did not modify locomotor activity. HU596 was not effective. The interference with aversive effects of naloxone-precipitated MWD by oleoyl alanine was prevented by both a PPARα antagonist and a CB

conclusionsOleoyl alanine (also an endogenous fatty acid) may be a more stable and effective treatment for opiate withdrawal than oleoyl glycine.

Indexed as

AlanineAnalgesics, OpioidAnimalsGlycineMaleMorphineMorphine DependenceNaloxoneNarcotic AntagonistsOleic AcidsRatsRats, Sprague-DawleyRewardSubstance Withdrawal SyndromeAlanineAnalgesics, OpioidGlycineMorphineNaloxoneNarcotic AntagonistsOleic AcidsoleoylglycineAnhedoniaCB1Conditioned place aversionNaloxone-precipitated morphine withdrawalNauseaOleoyl alanineOleoyl glycinePPARαRatSaccharin preferenceSomatic withdrawal

Identifiers

PMID32556401
OpenAlexW3036645513

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.