Evidence map›Paper›PMID 32556194›Full record

Trial reportInternational health2021

Indirect effect of oral azithromycin on the gut resistome of untreated children: a randomized controlled trial.

Catherine E Oldenburg, Armin Hinterwirth, Lee Worden, Ali Sié, Clarisse Dah, Lucienne Ouermi, Boubacar Coulibaly, Lina Zhong, Cindi Chen, Kevin Ruder and 3 more

Registry-linked trialOpen access · goldAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in International health, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03187834 (Antibiotic Resistance and Microbiome in Children Aged 6-59 Months in Nouna, Burkina Faso), which is not on this map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.1field-weighted citation impact, top 55% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03187834 phase4completednot on this map

Antibiotic Resistance and Microbiome in Children Aged 6-59 Months in Nouna, Burkina Faso

TypeinterventionalSponsorUniversity of California, San FranciscoRan2017 to 2019Enrolled252ConditionsChild DevelopmentArmsAzithromycin, Amoxicillin, Cotrimoxazole, Placebo
3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Trial
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 2 institutions in 2 countries.

Catherine E OldenburgFrancis I Proctor Foundation, 513 Parnassus Avenue, University of California, San Francisco, San Francisco, CA 94143, USA.
Armin HinterwirthFrancis I Proctor Foundation, 513 Parnassus Avenue, University of California, San Francisco, San Francisco, CA 94143, USA.
Lee WordenFrancis I Proctor Foundation, 513 Parnassus Avenue, University of California, San Francisco, San Francisco, CA 94143, USA.
Ali SiéCentre de Recherche en Santé de Nouna, Rue Namory Keita, Nouna, Burkina Faso.
Clarisse DahCentre de Recherche en Santé de Nouna, Rue Namory Keita, Nouna, Burkina Faso.
Lucienne OuermiCentre de Recherche en Santé de Nouna, Rue Namory Keita, Nouna, Burkina Faso.
Boubacar CoulibalyCentre de Recherche en Santé de Nouna, Rue Namory Keita, Nouna, Burkina Faso.
Lina ZhongFrancis I Proctor Foundation, 513 Parnassus Avenue, University of California, San Francisco, San Francisco, CA 94143, USA.
Cindi ChenFrancis I Proctor Foundation, 513 Parnassus Avenue, University of California, San Francisco, San Francisco, CA 94143, USA.
Kevin RuderFrancis I Proctor Foundation, 513 Parnassus Avenue, University of California, San Francisco, San Francisco, CA 94143, USA.
Thomas M LietmanFrancis I Proctor Foundation, 513 Parnassus Avenue, University of California, San Francisco, San Francisco, CA 94143, USA.
Jeremy D KeenanFrancis I Proctor Foundation, 513 Parnassus Avenue, University of California, San Francisco, San Francisco, CA 94143, USA.
Thuy DoanFrancis I Proctor Foundation, 513 Parnassus Avenue, University of California, San Francisco, San Francisco, CA 94143, USA.
University of California, San Francisco · USCentre de Recherche en Santé de Nouna · BF

Funding

The Brown Initiative in HIV and AIDS Clinical Research for Minority CommunitiesR25MH083620 · NIMH · MIRIAM HOSPITAL · PI NUNN, AMY STEWART · 2008 to 2025
$3.7M
NIMH NIH HHS R25 MH083620
6 · The paper itself

Abstract

backgroundAntibiotic use by one individual may affect selection for antimicrobial resistance in close contacts. Here we evaluated whether oral antibiotic treatment of one child within a household affected the gut resistome of an untreated cohabiting child.

methodsHouseholds with at least two children <5 y of age were randomized in a 1:1 fashion to a 5d course of azithromycin or placebo. To evaluate indirect effects of azithromycin treatment on the gut resistome, we randomly assigned one child in the house to azithromycin and one to placebo. In placebo households, each child received placebo. We performed DNA sequencing of rectal swabs collected 5 d after the last antibiotic dose. We estimated risk ratios for the presence of genetic resistance determinants at the class level using modified Poisson models for children in azithromycin households compared with placebo households and assessed the composition of the resistome using permutational analysis of variance (PERMANOVA).

resultsOf 58 children (n = 30 azithromycin households, n = 28 placebo households) with post-treatment rectal swabs, genetic resistance determinants were common but there was no significant difference at the class (p = 0.54 for macrolides) or gene (p = 0.94 for structure by PERMANOVA, p = 0.94 for diversity) level between untreated children in azithromycin households compared with placebo households.

conclusionsThe results are encouraging that one child's antibiotic use may not influence the resistome of another child. Trial registration: ClinicalTrials.gov NCT03187834.

Indexed as

AzithromycinMacrolidesAdministration, OralAnti-Bacterial AgentsChildHumansAnti-Bacterial AgentsAzithromycinMacrolidesantimicrobial resistanceazithromycinrandomized controlled trial

Identifiers

PMID32556194
PMCPMC7902679
OpenAlexW3036671257

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.