ArticleDatabase : the journal of biological databases and curation2020
FOBI: an ontology to represent food intake data and associate it with metabolomic data.
Article in Database : the journal of biological databases and curation, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed.
- A Polyphenol-Rich Diet Increases the Gut Microbiota Metabolite Indole 3-Propionic Acid in Older Adults with Preserved Kidney Function.Molecular nutrition & food research · 2022Trial
- Tracking the Metabolites of Health and Disease Using Artificial Intelligence.Diseases (Basel, Switzerland) · 2026Review
- Insulin resistance as a potential driving force of parental obesity-induced adverse metabolic programming mechanisms in children with obesity.BMC medicine · 2025Article
- Article
- Probing erythrocytes as sensitive and reliable sensors of metabolic disturbances in the crosstalk between childhood obesity and insulin resistance: findings from an observational study, in vivo challenge tests, and ex vivo incubation assays.Cardiovascular diabetology · 2024Observational
- Identifying metabotypes of insulin resistance severity in children with metabolic syndrome.Cardiovascular diabetology · 2024Article
- ChemFOnt: the chemical functional ontology resource.Nucleic acids research · 2023Article
- High-Throughput Method for Wide-Coverage and Quantitative Phenolic Fingerprinting in Plant-Origin Foods and Urine Samples.Journal of agricultural and food chemistry · 2022Article
- Applications of knowledge graphs for food science and industry.Patterns (New York, N.Y.) · 2022Review
- Developing a Dietary Lifestyle Ontology to Improve the Interoperability of Dietary Data: Proof-of-Concept Study.JMIR formative research · 2022Article
- Opportunities and Challenges of Integrating Food Practice into Clinical Decision-Making.Applied clinical informatics · 2022Article
- Assessing Adherence to Healthy Dietary Habits Through the Urinary Food Metabolome: Results From a European Two-Center Study.Frontiers in nutrition · 2022Article
- Food and Microbiota Metabolites Associate with Cognitive Decline in Older Subjects: A 12-Year Prospective Study.Molecular nutrition & food research · 2021Article
- Development of an Unified Food Composition Database for the European Project "Stance4Health".Nutrients · 2021Article
- New software tools, databases, and resources in metabolomics: updates from 2020.Metabolomics : Official journal of the Metabolomic Society · 2021Review
- Article
- The landscape of nutri-informatics: a review of current resources and challenges for integrative nutrition research.Database : the journal of biological databases and curation · 2021Review
- Quantifying the human diet in the crosstalk between nutrition and health by multi-targeted metabolomics of food and microbiota-derived metabolites.International journal of obesity (2005) · 2020Article
- Wine's Phenolic Compounds and Health: A Pythagorean View.Molecules (Basel, Switzerland) · 2020Review
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Nutrition research can be conducted by using two complementary approaches: (i) traditional self-reporting methods or (ii) via metabolomics techniques to analyze food intake biomarkers in biofluids. However, the complexity and heterogeneity of these two very different types of data often hinder their analysis and integration. To manage this challenge, we have developed a novel ontology that describes food and their associated metabolite entities in a hierarchical way. This ontology uses a formal naming system, category definitions, properties and relations between both types of data. The ontology presented is called FOBI (Food-Biomarker Ontology) and it is composed of two interconnected sub-ontologies. One is a 'Food Ontology' consisting of raw foods and 'multi-component foods' while the second is a 'Biomarker Ontology' containing food intake biomarkers classified by their chemical classes. These two sub-ontologies are conceptually independent but interconnected by different properties. This allows data and information regarding foods and food biomarkers to be visualized in a bidirectional way, going from metabolomics to nutritional data or vice versa. Potential applications of this ontology include the annotation of foods and biomarkers using a well-defined and consistent nomenclature, the standardized reporting of metabolomics workflows (e.g. metabolite identification, experimental design) or the application of different enrichment analysis approaches to analyze nutrimetabolomic data. Availability: FOBI is freely available in both OWL (Web Ontology Language) and OBO (Open Biomedical Ontologies) formats at the project's Github repository (https://github.com/pcastellanoescuder/FoodBiomarkerOntology) and FOBI visualization tool is available in https://polcastellano.shinyapps.io/FOBI_Visualization_Tool/.
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