ArticlePLoS pathogens2020
Patient genetics is linked to chronic wound microbiome composition and healing.
Article in PLoS pathogens, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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Who cites it
31 citing papers in PubMed, 62 citations in OpenAlex.
- Nasal microbiome and the effect of nasal decolonization with a novel povidone-iodine antiseptic solution: a prospective and randomized clinical trial.Scientific reports · 2024Trial
- Integrated analysis of the diabetic foot ulcer microbiome and host transcriptome supports a microenvironment-microbiota-host repair framework.Endocrine · 2026Article
- Phylogenetic Profiling of the Diabetic Foot Ulcer Microbiome of an Afro-Caribbean Population.MicrobiologyOpen · 2026Article
- The Multifaceted Properties of Copper and Zinc in Skin Healing.Dermatology and therapy · 2026Article
- Understanding and Advancing Wound Healing in the Era of Multi-Omic Technology.Bioengineering (Basel, Switzerland) · 2025Review
- Functionally enriched human polymorphisms associate to species in the chronic wound microbiome.NPJ biofilms and microbiomes · 2025Article
- Nanostructured Dual-Delivery System with Antioxidant and Synergistic Approach for Targeted Dermal Treatment.International journal of molecular sciences · 2025Article
- Revealing the promising era of silk-based nanotherapeutics: a ray of hope for chronic wound healing treatment.Naunyn-Schmiedeberg's archives of pharmacology · 2025Review
- A STRUCTURAL EQUATION MODEL PREDICTS CHRONIC WOUND HEALING TIME USING PATIENT CHARACTERISTICS AND WOUND MICROBIOME COMPOSITION.medRxiv : the preprint server for health sciences · 2025Article
- Assessment of potential genetic markers for diabetic foot ulcer among Moscow residents.Endocrine · 2024Article
- Exploring Condition-Specific Variability in the Ureteral Stent Microbiome.Pathogens (Basel, Switzerland) · 2024Article
- Clinical Evaluation of Microbial Communities and Associated Biofilms with Breast Augmentation Failure.Microorganisms · 2024Article
- Peptide clustering enhances large-scale analyses and reveals proteolytic signatures in mass spectrometry data.Nature communications · 2024Article
- The wound microbiota: microbial mechanisms of impaired wound healing and infection.Nature reviews. Microbiology · 2024Review
- Host-Microbiome Crosstalk in Chronic Wound Healing.International journal of molecular sciences · 2024Review
- The HEDGEHOG-GLI1 pathway is important for fibroproliferative properties in keloids and as a candidate therapeutic target.Communications biology · 2023Article
- Genetic parameters of sole lesion recovery in Holstein cows.Journal of dairy science · 2023Article
- Colonizing microbiota is associated with clinical outcomes in diabetic wound healing.Advanced drug delivery reviews · 2023Review
- Biofilm-Associated Infections in Chronic Wounds and Their Management.Advances in experimental medicine and biology · 2023Article
- Evolutionary Origins of Metabolic Reprogramming in Cancer.International journal of molecular sciences · 2022Review
Corrections and comments
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Authors and funding
12 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The clinical importance of microbiomes to the chronicity of wounds is widely appreciated, yet little is understood about patient-specific processes shaping wound microbiome composition. Here, a two-cohort microbiome-genome wide association study is presented through which patient genomic loci associated with chronic wound microbiome diversity were identified. Further investigation revealed that alternative TLN2 and ZNF521 genotypes explained significant inter-patient variation in relative abundance of two key pathogens, Pseudomonas aeruginosa and Staphylococcus epidermidis. Wound diversity was lowest in Pseudomonas aeruginosa infected wounds, and decreasing wound diversity had a significant negative linear relationship with healing rate. In addition to microbiome characteristics, age, diabetic status, and genetic ancestry all significantly influenced healing. Using structural equation modeling to identify common variance among SNPs, six loci were sufficient to explain 53% of variation in wound microbiome diversity, which was a 10% increase over traditional multiple regression. Focusing on TLN2, genotype at rs8031916 explained expression differences of alternative transcripts that differ in inclusion of important focal adhesion binding domains. Such differences are hypothesized to relate to wound microbiomes and healing through effects on bacterial exploitation of focal adhesions and/or cellular migration. Related, other associated loci were functionally enriched, often with roles in cytoskeletal dynamics. This study, being the first to identify patient genetic determinants for wound microbiomes and healing, implicates genetic variation determining cellular adhesion phenotypes as important drivers of infection type. The identification of predictive biomarkers for chronic wound microbiomes may serve as risk factors and guide treatment by informing patient-specific tendencies of infection.
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