ArticlePLoS computational biology2020
Circuits with broken fibration symmetries perform core logic computations in biological networks.
Article in PLoS computational biology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed.
- Symmetries and synchronization from whole-neural activity in theProceedings of the National Academy of Sciences of the United States of America · 2025Article
- Complexity reduction by symmetry: Uncovering the minimal regulatory network for logical computation in bacteria.PLoS computational biology · 2025Article
- Symmetries in metabolic networks ofPNAS nexus · 2025Article
- Fibration symmetry-breaking supports functional transitions in a brain network engaged in language.ArXiv · 2024Article
- Dynamics and bifurcations in genetic circuits with fibration symmetries.Journal of the Royal Society, Interface · 2024Article
- Fibration symmetry-breaking supports functional transitions in a brain network engaged in language.Research square · 2024Article
- Article
- Breaking reflection symmetry: evolving long dynamical cycles in Boolean systems.New journal of physics · 2024Article
- Fibration symmetries and cluster synchronization in the Caenorhabditis elegans connectome.PloS one · 2024Article
- Fast algorithm to identify minimal patterns of synchrony through fibration symmetries in large directed networks.Chaos (Woodbury, N.Y.) · 2022Article
- Predicting synchronized gene coexpression patterns from fibration symmetries in gene regulatory networks in bacteria.BMC bioinformatics · 2021Article
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Authors and funding
6 authors.
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Abstract
We show that logic computational circuits in gene regulatory networks arise from a fibration symmetry breaking in the network structure. From this idea we implement a constructive procedure that reveals a hierarchy of genetic circuits, ubiquitous across species, that are surprising analogues to the emblematic circuits of solid-state electronics: starting from the transistor and progressing to ring oscillators, current-mirror circuits to toggle switches and flip-flops. These canonical variants serve fundamental operations of synchronization and clocks (in their symmetric states) and memory storage (in their broken symmetry states). These conclusions introduce a theoretically principled strategy to search for computational building blocks in biological networks, and present a systematic route to design synthetic biological circuits.
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