ArticleScientific reports2020
Selective detection of phospholipids using molecularly imprinted fluorescent sensory core-shell particles.
Article in Scientific reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 29 citations in OpenAlex.
- [Design and synthesis of molecularly imprinted polymers and their applications in medical diagnosis and biocatalysis].Se pu = Chinese journal of chromatography · 2026Review
- [Molecular imprinting strategies and advances targeting biomembranes].Se pu = Chinese journal of chromatography · 2026Review
- Development of molecularly imprinted polymers for the detection of human chorionic gonadotropin.Scientific reports · 2025Article
- Enhanced selective capture of phosphomonoester lipids enabling highly sensitive detection of sphingosine 1-phosphate.Analytical and bioanalytical chemistry · 2023Article
- Molecularly Imprinted Polymer-Based Luminescent Chemosensors.Biosensors · 2023Review
- Thiourea- and Amino-Substituted Benzoxadiazole Dyes with Large Stokes Shifts as Red-Emitting Probe Monomers for Imprinted Polymer Layers Targeting Carboxylate-Containing Antibiotics.Chemistry (Weinheim an der Bergstrasse, Germany) · 2022Article
- Tailored Polymer-Based Selective Extraction of Lipid Mediators from Biological Samples.Metabolites · 2021Article
- Typical Fluorescent Sensors Exploiting Molecularly Imprinted Hydrogels for Environmentally and Medicinally Important Analytes Detection.Gels (Basel, Switzerland) · 2021Article
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Authors and funding
10 authors at 3 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Sphingosine-1-phosphate (S1P) is a bioactive sphingo-lipid with a broad range of activities coupled to its role in G-protein coupled receptor signalling. Monitoring of both intra and extra cellular levels of this lipid is challenging due to its low abundance and lack of robust affinity assays or sensors. We here report on fluorescent sensory core-shell molecularly imprinted polymer (MIP) particles responsive to near physiologically relevant levels of S1P and the S1P receptor modulator fingolimod phosphate (FP) in spiked human serum samples. Imprinting was achieved using the tetrabutylammonium (TBA) salt of FP or phosphatidic acid (DPPA·Na) as templates in combination with a polymerizable nitrobenzoxadiazole (NBD)-urea monomer with the dual role of capturing the phospho-anion and signalling its presence. The monomers were grafted from ca 300 nm RAFT-modified silica core particles using ethyleneglycol dimethacrylate (EGDMA) as crosslinker resulting in 10-20 nm thick shells displaying selective fluorescence response to the targeted lipids S1P and DPPA in aqueous buffered media. Potential use of the sensory particles for monitoring S1P in serum was demonstrated on spiked serum samples, proving a linear range of 18-60 µM and a detection limit of 5.6 µM, a value in the same range as the plasma concentration of the biomarker.
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