ArticleScientific reports2020
Draft genome of the European medicinal leech Hirudo medicinalis (Annelida, Clitellata, Hirudiniformes) with emphasis on anticoagulants.
Article in Scientific reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed, 60 citations in OpenAlex.
- Hirudins and ornatins in five species of the genus Placobdella (Annelida: Hirudinea: Glossiphoniidae).Protoplasma · 2026Article
- Hookworm genes encoding intestinal excreted-secreted proteins are transcriptionally upregulated in response to the host's immune system.PLoS neglected tropical diseases · 2026Article
- Monomeric and Oligomeric Decorsins of the Asian Medicinal LeechInternational journal of molecular sciences · 2025Article
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- Comparative Study of Hirudins and Encoding Genes inBiology · 2025Article
- The development and application of mini-barcodes from mitochondrial DNA for identifying medicinal leeches from traditional medicines.Scientific reports · 2025Article
- Chromosome-level genome assembly and anticoagulant protein annotation of the buffalo leech Hirudinaria bpling (Hirudinea: Hirudinidae).BMC genomics · 2025Article
- ERGA-BGE reference genome ofOpen research Europe · 2025Article
- Comparative genomics of three non-hematophagous leeches (Frontiers in genetics · 2025Article
- Diversity of hirudin and hirudin-like factor genes in the North-African medicinal leech, Hirudo troctina.Parasitology research · 2024Article
- Acceleration of genome rearrangement in clitellate annelids.bioRxiv : the preprint server for biology · 2024Article
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- Revisiting the Asian Buffalo Leech (Genes · 2023Article
- Structural insights into thrombolytic activity of destabilase from medicinal leech.Scientific reports · 2023Article
- Division of developmental phases of freshwater leech Whitmania pigra and key genes related to neurogenesis revealed by whole genome and transcriptome analysis.BMC genomics · 2023Article
- Highly Dynamic Gene Family Evolution Suggests Changing Roles for PON Genes Within Metazoa.Genome biology and evolution · 2023Article
- Molecular mechanisms underlying hematophagia revealed by comparative analyses of leech genomes.GigaScience · 2022Article
- Make it double: identification and characterization of a Tandem-Hirudin from the Asian medicinal leech Hirudinaria manillensis.Parasitology research · 2022Article
- The genome of medicinal leech (Whitmania pigra) and comparative genomic study for exploration of bioactive ingredients.BMC genomics · 2022Article
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Authors and funding
5 authors at 5 institutions in 4 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The European medicinal leech has been used for medicinal purposes for millennia, and continues to be used today in modern hospital settings. Its utility is granted by the extremely potent anticoagulation factors that the leech secretes into the incision wound during feeding and, although a handful of studies have targeted certain anticoagulants, the full range of anticoagulation factors expressed by this species remains unknown. Here, we present the first draft genome of the European medicinal leech, Hirudo medicinalis, and estimate that we have sequenced between 79-94% of the full genome. Leveraging these data, we searched for anticoagulation factors across the genome of H. medicinalis. Following orthology determination through a series of BLAST searches, as well as phylogenetic analyses, we estimate that fully 15 different known anticoagulation factors are utilized by the species, and that 17 other proteins that have been linked to antihemostasis are also present in the genome. We underscore the utility of the draft genome for comparative studies of leeches and discuss our results in an evolutionary context.
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