Evidence map›Paper›PMID 32555460›Full record

ArticleNature2020

Structural basis of the activation of a metabotropic GABA receptor.

Hamidreza Shaye, Andrii Ishchenko, Jordy Homing Lam, Gye Won Han, Li Xue, Philippe Rondard, Jean-Philippe Pin, Vsevolod Katritch, Cornelius Gati, Vadim Cherezov

Open access · greenAbstract read
In one paragraph

Article in Nature, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 84 papers.

0numbers the graph read from it
0cells of the map it votes in
84citing papers in PubMed
9.4field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

84 citing papers in PubMed, 148 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Review
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Review
  11. GPCR Heterodimers: Implications for Biased Signaling.Handbook of experimental pharmacology · 2026
    Review
  12. GABAFrontiers in pharmacology · 2026
    Review
  13. Article
  14. GABA-independent activation of GABANature communications · 2025
    Article
  15. Structural Basis of GABAAdvanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025
    Article
  16. Article
  17. Article
  18. Article
  19. GABAMedComm · 2025
    Review
  20. Review

24 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 2 countries.

Hamidreza ShayeBridge Institute, USC Michelson Center for Convergent Biosciences, University of Southern California, Los Angeles, CA, USA.ORCID http://orcid.org/0000-0002-8670-1259
Andrii IshchenkoBridge Institute, USC Michelson Center for Convergent Biosciences, University of Southern California, Los Angeles, CA, USA.ORCID http://orcid.org/0000-0002-3797-0604
Jordy Homing LamBridge Institute, USC Michelson Center for Convergent Biosciences, University of Southern California, Los Angeles, CA, USA.
Gye Won HanBridge Institute, USC Michelson Center for Convergent Biosciences, University of Southern California, Los Angeles, CA, USA.
Li XueInstitut de Génomique Fonctionnelle (IGF), CNRS, INSERM, Université de Montpellier, Montpellier, France.ORCID http://orcid.org/0000-0003-0650-2194
Philippe RondardInstitut de Génomique Fonctionnelle (IGF), CNRS, INSERM, Université de Montpellier, Montpellier, France.ORCID http://orcid.org/0000-0003-1134-2738
Jean-Philippe PinInstitut de Génomique Fonctionnelle (IGF), CNRS, INSERM, Université de Montpellier, Montpellier, France.ORCID http://orcid.org/0000-0002-1423-345X
Vsevolod KatritchBridge Institute, USC Michelson Center for Convergent Biosciences, University of Southern California, Los Angeles, CA, USA.ORCID http://orcid.org/0000-0003-3883-4505
Cornelius GatiBiosciences Division, SLAC National Accelerator Laboratory, Menlo Park, CA, USA. cgati@stanford.edu.ORCID http://orcid.org/0000-0003-3693-7009
Vadim CherezovBridge Institute, USC Michelson Center for Convergent Biosciences, University of Southern California, Los Angeles, CA, USA. cherezov@usc.edu.ORCID http://orcid.org/0000-0002-5265-3914
University of Southern California · USCentre National de la Recherche Scientifique · FRSLAC National Accelerator Laboratory · US

Funding

Structural Biology Of G Protein-Coupled ReceptorsR35GM127086 · NIGMS · UNIVERSITY OF SOUTHERN CALIFORNIA · PI Vadim Cherezov · 2018 to 2026
$3.6M
NIGMS NIH HHS R35 GM127086
6 · The paper itself

Abstract

Metabotropic γ-aminobutyric acid receptors (GABA

Indexed as

Cryoelectron MicroscopyAllosteric RegulationApoproteinsBinding SitesGABA-B Receptor AgonistsHumansModels, MolecularProtein DomainsProtein MultimerizationReceptors, GABA-BSignal TransductionStructure-Activity RelationshipApoproteinsGABA-B Receptor AgonistsReceptors, GABA-B

Identifiers

PMID32555460
PMCPMC8020835
OpenAlexW3036443046

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.