ArticleNature2020
Senolytic CAR T cells reverse senescence-associated pathologies.
Erratum issued Registry-linked trialOpen access · greenAbstract read
In one paragraph
Article in Nature, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. It is linked to trial NCT05637216 (A Pilot Study of Losartan to Reduce Radiation Induced Fibrosis in Breast Cancer Patients), which is not on this map. Cited by 719 papers, 2 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
719citing papers in PubMed, 2 pooled it
39.7field-weighted citation impact, top 1% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
NCT05637216 phase2active not recruitingnot on this mapstarted 2023, after this paper: background citation
A Pilot Study of Losartan to Reduce Radiation Induced Fibrosis in Breast Cancer Patients
Who cites it
719 citing papers in PubMed, 2 syntheses or guidelines pooled it, 986 citations in OpenAlex.
- Novel Therapeutic Strategies for Metastatic Prostate Cancer Care.European urology · 2025Pooled it
- Cross-Trait Meta-Analysis Reveals a Genetic Link between Inflammation and Aging in Giant Cell Arteritis.Aging and disease · 2025Pooled it
- A dual-targeting mRNA lipid nanoparticle restores ABCA1-dependent cholesterol homeostasis to promote repair of age-related bone defects.Bioactive materials · 2027Article
- Human T cell engineering via serial delivery of mRNA encapsulated within lipid nanoparticles.Molecular therapy. Nucleic acids · 2026Article
- Plasma proteomic biomarkers as mediators for the associations between frailty phenotypes and chronic respiratory diseases.GeroScience · 2026Article
- Hepatocyte senescence in metabolic dysfunction-associated steatotic liver disease (MASLD).Hepatology communications · 2026Review
- Next-generation natural killer cell therapy: bench to bedside and beyond.Signal transduction and targeted therapy · 2026Review
- The METTL3/LOXL2 axis participates in aberrant epithelial-fibroblast crosstalk and induces oral submucous fibrosis in rats.Molecular and cellular biochemistry · 2026Article
- Cellular senescence: six decades of discovery and reinvention.The EMBO journal · 2026Review
- uPAR-Targeting T Cell Engager Exerts Senolytic Effects in Mice and Non-Human Primates With Serum Aminotransferase Activity as a Safety Monitor.Aging cell · 2026Article
- Chimeric antigen receptor T (CAR-T) cell therapy in non-oncological diseases.Signal transduction and targeted therapy · 2026Review
- Cellular senescence and regulated cell death in cancer: mechanisms, cross-regulatory networks and therapeutic implications.Journal of hematology & oncology · 2026Review
- T-Cell Remodeling in Renal Fibrosis: From Acute Injury to Chronic Kidney Disease.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Review
- Senescence-directed nanotherapy ameliorates fibrosis and overcomes immune exclusion in cancer.Science (New York, N.Y.) · 2026Article
- The role of senescence in kidney ageing, injury and fibrosis.Nature reviews. Nephrology · 2026Review
- Beyond Oncology: Exploring the Expanding Role of CAR T Cell Therapy in Autoimmune and Infectious Diseases-A Systematic Review.Pathophysiology : the official journal of the International Society for Pathophysiology · 2026Review
- The vicious cycle of SASP and inflammaging promotes aging and age-related diseases.Communications biology · 2026Review
- Therapy induced senescence promotes immunogenicity in acute myeloid Leukemia through reduced EZH2 activity.Nature communications · 2026Article
- Review
- Targeting senescent cells with dipeptidyl peptidase 4-CAR-NK cells alleviates liver fibrosis and reverses metabolic dysfunction.Acta pharmaceutica Sinica. B · 2026Article
659 more citing papers are in PubMed but not listed here.
Corrections and comments
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- Erratum issued
Authors and funding
18 authors at 2 institutions in 1 country.
Corina Amor *Louis V. Gerstner Jr Graduate School of Biomedical Sciences, Memorial Sloan Kettering Cancer Center, New York, NY, USA.ORCID http://orcid.org/0000-0002-7654-6216
Judith Feucht *Center for Cell Engineering, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Josef Leibold *Department of Cancer Biology and Genetics, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Yu-Jui HoDepartment of Cancer Biology and Genetics, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Changyu ZhuDepartment of Cancer Biology and Genetics, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Direna Alonso-CurbeloDepartment of Cancer Biology and Genetics, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Jorge Mansilla-SotoCenter for Cell Engineering, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Jacob A BoyerLouis V. Gerstner Jr Graduate School of Biomedical Sciences, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Xiang LiDepartment of Cancer Biology and Genetics, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Theodoros GiavridisCenter for Cell Engineering, Memorial Sloan Kettering Cancer Center, New York, NY, USA.ORCID http://orcid.org/0000-0002-8716-781X
Amanda KulickMolecular Pharmacology and Chemistry Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Shauna HoulihanDepartment of Cancer Biology and Genetics, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Ellinor PeerschkeDepartment of Laboratory Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Scott L FriedmanDivision of Liver Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA.ORCID http://orcid.org/0000-0003-1178-6195
Vladimir PonomarevDepartment of Radiology, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Alessandra PiersigilliLaboratory of Comparative Pathology, Rockefeller University, Weill Cornell Medicine and Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Michel SadelainCenter for Cell Engineering, Memorial Sloan Kettering Cancer Center, New York, NY, USA. m-sadelain@ski.mskcc.org.
Scott W LoweDepartment of Cancer Biology and Genetics, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY, USA. lowes@mskcc.org.ORCID http://orcid.org/0000-0002-5284-9650
Memorial Sloan Kettering Cancer Center · USIcahn School of Medicine at Mount Sinai · US
Funding
X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Hongbiao Carl Lekaye · 1985 to 2026
$347.4MThe Role of Focal Oncogene Amplifications in Lung CancerP01CA129243 · NCI · SLOAN-KETTERING INST CAN RESEARCH · PI Marc Ladanyi · 2007 to 2026
$31.2MMSKCC Pilot Center for Precision Disease ModelingU54OD020355 · OD · SLOAN-KETTERING INST CAN RESEARCH · PI LOWE, SCOTT W., SOLIT, DAVID B. · 2015 to 2019
$9.9MThe Role of KLF6 in Hepatic FibrosisR01DK056621 · NIDDK · MOUNT SINAI SCHOOL OF MEDICINE OF NYU · PI FRIEDMAN, SCOTT L. · 2000 to 2019
$6.2MRas Induced Senescence and Tumor SuppressionR01AG016379 · NIA · SLOAN-KETTERING INST CAN RESEARCH · PI LOWE, SCOTT W. · 1999 to 2014
$5.6MToward development of senolytic CAR T cellsR01AG065396 · NIA · SLOAN-KETTERING INST CAN RESEARCH · PI LOWE, SCOTT W., SADELAIN, MICHEL WJ · 2020 to 2024
$2.7MRAS Induced Senescence and Tumor SuppressionR56AG016379 · NIA · SLOAN-KETTERING INST CAN RESEARCH · PI LOWE, SCOTT W. · 2015 to 2015
$435kNCI NIH HHS P01 CA129243NCI NIH HHS P30 CA008748NCI NIH HHS U54 OD020355-01NIA NIH HHS AG065396NIA NIH HHS R01 AG016379NIA NIH HHS R01 AG065396NIA NIH HHS R56 AG016379NIDDK NIH HHS R01 DK056621NIH HHS U54 OD020355
Abstract
Cellular senescence is characterized by stable cell-cycle arrest and a secretory program that modulates the tissue microenvironment
Indexed as
RejuvenationAdenocarcinomaAgingAnimalsCarbon TetrachlorideCellular SenescenceFemaleHeterograftsHumansLiver CirrhosisLongevityLung NeoplasmsMaleMiceReceptors, Cell SurfaceReceptors, Chimeric AntigenCarbon TetrachlorideReceptors, Cell SurfaceReceptors, Chimeric AntigenReceptors, Urokinase Plasminogen Activator
Identifiers
What OpenQuestion holds
Textmetadata
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Read underepoch 390
Registered trials
NCT05637216ClinicalTrials.gov
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.