Evidence map›Paper›PMID 32555456›Full record

ArticleNature2020

A neurotransmitter produced by gut bacteria modulates host sensory behaviour.

Michael P O'Donnell, Bennett W Fox, Pin-Hao Chao, Frank C Schroeder, Piali Sengupta

Open access · greenAbstract read
In one paragraph

Article in Nature, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 145 papers.

0numbers the graph read from it
0cells of the map it votes in
145citing papers in PubMed
12.8field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

145 citing papers in PubMed, 271 citations in OpenAlex.

  1. Trial
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  11. Epigenetic constraints and enhancer innovation link neuronal plasticity to evolutionary adaptation.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  12. Article
  13. Review
  14. Can bacteria control the human brain?Communicative & integrative biology · 2026
    Review
  15. Review
  16. Article
  17. Review
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  19. Article
  20. Hemocyanin controlsVirulence · 2025
    Article

85 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Michael P O'DonnellDepartment of Biology, Brandeis University, Waltham, MA, USA. mikeod@brandeis.edu.ORCID http://orcid.org/0000-0001-8313-8969
Bennett W FoxBoyce Thompson Institute and Department of Chemistry and Chemical Biology, Cornell University, Ithaca, NY, USA.
Pin-Hao ChaoDepartment of Biology, Brandeis University, Waltham, MA, USA.ORCID http://orcid.org/0000-0003-3766-0419
Frank C SchroederBoyce Thompson Institute and Department of Chemistry and Chemical Biology, Cornell University, Ithaca, NY, USA.
Piali SenguptaDepartment of Biology, Brandeis University, Waltham, MA, USA. sengupta@brandeis.edu.ORCID http://orcid.org/0000-0001-7468-0035
Brandeis University · USCornell University · US

Funding

Quantitative Neuroscience: Tools for Bridging Levels of AnalysisT32NS007292 · NINDS · BRANDEIS UNIVERSITY · PI GINA G TURRIGIANO · 1986 to 2026
$12.7M
Mechanisms of sensory neuron morphological diversification, signaling, and functional plasticityR35GM122463 · NIGMS · BRANDEIS UNIVERSITY · PI Piali Sengupta · 2017 to 2026
$7.7M
Small molecule signaling in C. elegansR35GM131877 · NIGMS · BOYCE THOMPSON INST FOR PLANT RESEARCH · PI Frank Clemens Schroeder · 2019 to 2026
$5.0M
Small Molecule Signaling in Caenorhabditis elegansR01GM088290 · NIGMS · BOYCE THOMPSON INST FOR PLANT RESEARCH · PI SCHROEDER, FRANK CLEMENS · 2010 to 2017
$2.2M
Modulation of chemosensory behaviors by gut microbiotaR21NS101702 · NINDS · BRANDEIS UNIVERSITY · PI SENGUPTA, PIALI · 2017 to 2018
$447k
Genetic and neural basis of pheromone sensory integration in nematodesF32DC013711 · NIDCD · BRANDEIS UNIVERSITY · PI ODONNELL, MICHAEL PATRICK · 2013 to 2015
$103k
NIDCD NIH HHS F32 DC013711NIGMS NIH HHS R01 GM088290NIGMS NIH HHS R35 GM122463NIGMS NIH HHS R35 GM131877NINDS NIH HHS R21 NS101702NINDS NIH HHS T32 NS007292
6 · The paper itself

Abstract

Animals coexist in commensal, pathogenic or mutualistic relationships with complex communities of diverse organisms, including microorganisms

Indexed as

AnimalsAvoidance LearningCaenorhabditis elegansCaenorhabditis elegans ProteinsFeeding BehaviorGastrointestinal MicrobiomeIntestinesMetabolomicsMutationNeurotransmitter AgentsOctanolsOctopamineProvidenciaReceptors, Biogenic AmineReceptors, G-Protein-CoupledSensory Receptor CellsCaenorhabditis elegans ProteinsNeurotransmitter Agentsnorsynephrine receptorOctanolsOctopamineOCTR-1 protein, C elegansReceptors, Biogenic AmineReceptors, G-Protein-Coupledtdc-1 protein, C elegansTyramineTyrosine Decarboxylase

Identifiers

PMID32555456
PMCPMC7853625
OpenAlexW3035914962

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.