Evidence map›Paper›PMID 32555374›Full record

ArticleScientific reports2020

Regional Brain Gray Matter Changes in Patients with Type 2 Diabetes Mellitus.

Bhaswati Roy, Luke Ehlert, Rashmi Mullur, Matthew J Freeby, Mary A Woo, Rajesh Kumar, Sarah Choi

Registry-linked trialOpen access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06322212 (Type 2 Diabetes Mellitus and Blood Brain Barrier Improvement - A Randomized Clinical Trial), which is not on this map. Cited by 55 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
55citing papers in PubMed, 6 pooled it
6.3field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06322212 early_phase1recruitingnot on this mapstarted 2024, after this paper: background citation

Type 2 Diabetes Mellitus and Blood Brain Barrier Improvement - A Randomized Clinical Trial

TypeinterventionalSponsorUniversity of California, Los AngelesRan2024 to 2027Enrolled52ConditionsType2diabetesArmsThiamine, Placebo
3 · Its place in the literature

Who cites it

55 citing papers in PubMed, 6 syntheses or guidelines pooled it, 93 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Bhaswati RoyDepartment of Anesthesiology, University of California Los Angeles, Los Angeles, CA, 90095, USA.
Luke EhlertDepartment of Anesthesiology, University of California Los Angeles, Los Angeles, CA, 90095, USA.
Rashmi MullurDepartment of Medicine, University of California Los Angeles, Los Angeles, CA, 90095, USA.
Matthew J FreebyDepartment of Medicine, University of California Los Angeles, Los Angeles, CA, 90095, USA.
Mary A WooUCLA School of Nursing, University of California Los Angeles, Los Angeles, CA, 90095, USA.
Rajesh KumarDepartment of Anesthesiology, University of California Los Angeles, Los Angeles, CA, 90095, USA. rkumar@mednet.ucla.edu.
Sarah ChoiUCLA School of Nursing, University of California Los Angeles, Los Angeles, CA, 90095, USA.
University of California, Los Angeles · US

Funding

Relationships Between Brain Tissue Integrity and Self-Care Abilities in Adults with Type 2 Diabetes-Administrative SupplementR01NR017190 · NINR · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI CHOI, SARAH E, KUMAR, RAJESH · 2018 to 2021
$2.5M
NINR NIH HHS R01 NR017190
6 · The paper itself

Abstract

Patients with Type 2 diabetes mellitus (T2DM) show cognitive and mood impairment, indicating potential for brain injury in regions that control these functions. However, brain tissue integrity in cognition, anxiety, and depression regulatory sites, and their associations with these functional deficits in T2DM subjects remain unclear. We examined gray matter (GM) changes in 34 T2DM and 88 control subjects using high-resolution T1-weighted images, collected from a 3.0-Tesla magnetic resonance imaging scanner, and assessed anxiety [Beck Anxiety Inventory], depressive symptoms [Beck Depression Inventory-II], and cognition [Montreal Cognitive Assessment]. We also investigated relationships between GM status of cognitive and mood control sites and these scores in T2DM. Significantly increased anxiety (p = 0.003) and depression (p = 0.001), and reduced cognition (p = 0.002) appeared in T2DM over controls. Decreased GM volumes appeared in several regions in T2DM patients, including the prefrontal, hippocampus, amygdala, insular, cingulate, cerebellum, caudate, basal-forebrain, and thalamus areas (p < 0.01). GM volumes were significantly associated with anxiety (r = -0.456,p = 0.009), depression (r = -0.465,p = 0.01), and cognition (r = 0.455,p = 0.009) scores in regions associated with those regulations (prefrontal cortices, hippocampus, para hippocampus, amygdala, insula, cingulate, caudate, thalamus, and cerebellum) in T2DM patients. Patients with T2DM show brain damage in regions that are involved in cognition, anxiety, and depression control, and these tissue alterations are associated with functional deficits. The findings indicate that mood and cognitive deficits in T2DM patients has brain structural basis in the condition.

Indexed as

BrainBrain MappingCase-Control StudiesCognitive DysfunctionDiabetes Mellitus, Type 2FemaleFollow-Up StudiesGray MatterHumansIncidenceLos AngelesMagnetic Resonance ImagingMaleMiddle AgedPrognosis

Identifiers

PMID32555374
PMCPMC7303156
OpenAlexW3036591172

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.