Evidence map›Paper›PMID 32555345›Full record

ArticleScientific reports2020

PKA and Ube3a regulate SK2 channel trafficking to promote synaptic plasticity in hippocampus: Implications for Angelman Syndrome.

Jiandong Sun, Yan Liu, Guoqi Zhu, Caleb Cato, Xiaoning Hao, Li Qian, Weiju Lin, Rachana Adhikari, Yun Luo, Michel Baudry and 1 more

Open access · goldAbstract read
In one paragraph

Article in Scientific reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
1.6field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 15 citations in OpenAlex.

  1. Small-Conductance CaNeuroscience bulletin · 2026
    Review
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  12. Emerging Gene and Small Molecule Therapies for the Neurodevelopmental Disorder Angelman Syndrome.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2021
    Review
  13. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 2 countries.

Jiandong SunCollege of Osteopathic Medicine of the Pacific, Western University of Health Sciences, Pomona, CA, 91766, USA.ORCID http://orcid.org/0000-0003-4270-8704
Yan Liu *Graduate College of Biomedical Sciences, Western University of Health Sciences, Pomona, CA, 91766, USA.
Guoqi Zhu *Graduate College of Biomedical Sciences, Western University of Health Sciences, Pomona, CA, 91766, USA.
Caleb CatoCollege of Osteopathic Medicine of the Pacific, Western University of Health Sciences, Pomona, CA, 91766, USA.
Xiaoning HaoCollege of Osteopathic Medicine of the Pacific, Western University of Health Sciences, Pomona, CA, 91766, USA.
Li QianCollege of Pharmacy, Western University of Health Sciences, Pomona, CA, 91766, USA.
Weiju LinGraduate College of Biomedical Sciences, Western University of Health Sciences, Pomona, CA, 91766, USA.ORCID http://orcid.org/0000-0003-4578-4120
Rachana AdhikariCollege of Osteopathic Medicine of the Pacific, Western University of Health Sciences, Pomona, CA, 91766, USA.
Yun LuoCollege of Pharmacy, Western University of Health Sciences, Pomona, CA, 91766, USA.ORCID http://orcid.org/0000-0003-3581-754X
Michel BaudryGraduate College of Biomedical Sciences, Western University of Health Sciences, Pomona, CA, 91766, USA.
Xiaoning BiCollege of Osteopathic Medicine of the Pacific, Western University of Health Sciences, Pomona, CA, 91766, USA. xbi@westernu.edu.ORCID http://orcid.org/0000-0001-7449-7003
Western University of Health Sciences · USAnhui University of Traditional Chinese Medicine · CN

Funding

Ube3a and PKA regulation of SK2 channelsR15MH101703 · NIMH · WESTERN UNIVERSITY OF HEALTH SCIENCES · PI BI, XIAONING · 2014 to 2025
$1.7M
Roles of UBE3A-mediated p18 regulation in synaptogenesis and synaptic plasticityR01NS104078 · NINDS · WESTERN UNIVERSITY OF HEALTH SCIENCES · PI BAUDRY, MICHEL · 2018 to 2022
$1.5M
NIMH NIH HHS R15 MH101703NINDS NIH HHS R01 NS104078
6 · The paper itself

Abstract

The ubiquitin ligase, Ube3a, plays important roles in brain development and functions, since its deficiency results in Angelman Syndrome (AS) while its over-expression increases the risk for autism. We previously showed that the lack of Ube3a-mediated ubiquitination of the Ca

Indexed as

Neuronal PlasticityAmino Acid SequenceAngelman SyndromeAnimalsCA1 Region, HippocampalChlorocebus aethiopsCOS CellsCyclic AMP-Dependent Protein KinasesEndocytosisHippocampusLong-Term PotentiationMiceModels, MolecularMutationPhosphorylationProtein DomainsCyclic AMP-Dependent Protein KinasesKcnn2 protein, mouseSmall-Conductance Calcium-Activated Potassium ChannelsUbe3a protein, mouseUbiquitin-Protein Ligases

Identifiers

PMID32555345
PMCPMC7299966
OpenAlexW3035838166

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.