ArticleScientific reports2020
Comorbidities of Patients with Functional Somatic Syndromes Before, During and After First Diagnosis: A Population-based Study using Bavarian Routine Data.
Article in Scientific reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 27 citations in OpenAlex.
- Prospective associations between major depressive disorder, generalized anxiety disorder, fibromyalgia, and myalgic encephalomyelitis/chronic fatigue syndrome.Psychological medicine · 2025Article
- Efficacy of Cognitive Behavioral Therapy and Acceptance- and Mindfulness-Based Treatments in Adults with Bodily Distress: A Network Meta-Analysis.Psychotherapy and psychosomatics · 2025Article
- Frequency, persistence and relation of disease symptoms, psychosomatic comorbidity and daily life impairment after COVID-19: a cohort study in general practice.BMC primary care · 2024Article
- Functional somatic syndromes are associated with inferior outcomes and increased complications after hip and knee arthroplasty: a systematic review.Arthroplasty (London, England) · 2024Article
- Psychological flexibility and global health in young adults with and without a self-reported functional somatic syndrome: a preliminary investigation.Psychology, health & medicine · 2023Article
- Aetiological Understanding of Fibromyalgia, Irritable Bowel Syndrome, Chronic Fatigue Syndrome and Classificatory Analogues: A Systematic Umbrella Review.Clinical psychology in Europe · 2023Review
- A multidimensional longitudinal dataset on functional somatic syndromes.Data in brief · 2023Article
- Psychiatric disorders comorbid with general medical illnesses and functional somatic disorders: The Lifelines cohort study.PloS one · 2023Article
- The Role of Neuro-Immune Interaction in Chronic Pain Conditions; Functional Somatic Syndrome, Neurogenic Inflammation, and Peripheral Neuropathy.International journal of molecular sciences · 2022Review
- Patients With Somatoform Disorders Are Prone to Expensive and Potentially Harmful Medical Procedures—Results of a Retrospective Cohort Study Over 15 Years.Deutsches Arzteblatt international · 2021Article
- Under-recognition of medically unexplained symptom conditions among US Veterans with Gulf War Illness.PloS one · 2021Article
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Functional somatic syndromes (FSS) are characterised by the presence of one or multiple chronic symptoms that cannot be attributed to a known somatic disease. They are thought to arise though a complex interaction of biological and psychosocial factors, but it is unclear whether they share a common aetiology. One hypothesis supported by recent studies is that the FSS are postinfectious disorders, as is widely recognised for a subset of patients with irritable bowel syndrome. Our study used claims data submitted by office-based physicians to compare groups of patients with different FSS in the five years before and after the point of first diagnosis. Even five years prior to diagnosis, FSS patients consulted more frequently for a range of psychological and somatic conditions than did controls. Following diagnosis, consultation rates increased further and remained persistently high. Five years after diagnosis, between 34% (somatization disorder) and 66% (fibromyalgia) of patients were still being treated for the condition. Both prior gastrointestinal and upper-respiratory infection were associated with an increased risk of developing an FSS. We therefore recommend that patients at risk should be identified at an early stage and the underlying psychosocial and somatic issues addressed to prevent progression of the condition.
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