ArticleScientific reports2020
Ultrastructure imaging of Pseudomonas aeruginosa lawn biofilms and eradication of the tobramycin-resistant variants under in vitro electroceutical treatment.
Article in Scientific reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed.
- Article
- A bacterial pigment provides cross-species protection from HProceedings of the National Academy of Sciences of the United States of America · 2024Article
- Activity of a hypochlorous acid-producing electrochemical bandage as assessed with a porcine explant biofilm model.Biotechnology and bioengineering · 2023Article
- Antisense-acting riboswitches: A poorly characterized yet important model of transcriptional regulation in prokaryotic organisms.PloS one · 2023Article
- Electroceutical treatment of infected chronic wounds in a dog and a cat.Veterinary surgery : VS · 2022Article
- Exploration of the Pharmacodynamics for Pseudomonas aeruginosa Biofilm Eradication by Tobramycin.Antimicrobial agents and chemotherapy · 2022Article
- Potential of Bacterial Cellulose Chemisorbed with Anti-Metabolites, 3-Bromopyruvate or Sertraline, to Fight againstInternational journal of molecular sciences · 2020Article
- Review
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Authors and funding
8 authors.
Funding
Abstract
Electrochemically generated bactericidal compounds have been shown to eradicate bacterial lawn biofilms through electroceutical treatment. However, the ultrastructure of biofilms exposed to these species has not been studied. Moreover, it is unknown if the efficacy of electroceutical treatment extends to antibiotic-resistant variants that emerge in lawn biofilms after antibiotic treatment. In this report, the efficacy of the in vitro electroceutical treatment of Pseudomonas aeruginosa biofilms is demonstrated both at room temperature and in an incubator, with a ~4 log decrease (p < 0.01) in the biofilm viability observed over the anode at both conditions. The ultrastructure changes in the lawn biofilms imaged using transmission electron microscopy demonstrate significant bacterial cell damage over the anode after 24 h of electroceutical treatment. A mix of both damaged and undamaged cells was observed over the cathode. Finally, both eradication and prevention of the emergence of tobramycin-resistant variants were demonstrated by combining antibiotic treatment with electroceutical treatment on the lawn biofilms.
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