ArticleNature communications2020
Circadian regulation of hedonic appetite in mice by clocks in dopaminergic neurons of the VTA.
Article in Nature communications, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
21 citing papers in PubMed.
- Acarbose differentially affects gut microbial metabolism of maltose and sucrose, distinctly modulating host metabolism.iScience · 2026Article
- Circadian modulation of spontaneous dopamine release shapes reward-evoked signaling in the nucleus accumbens.bioRxiv : the preprint server for biology · 2026Article
- VTA-forebrain connectivity moderates adaptive behavior.Brain structure & function · 2026Review
- Disrupted circadian rhythms and opioid-mediated adverse effects: Bidirectional relationship and putative mechanisms.Journal of neuroendocrinology · 2025Review
- Weight Cycling Deregulates Eating Behavior in Mice via the Induction of Durable Gut Dysbiosis.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Brain circadian clocks timing the 24h rhythms of behavior.Npj biological timing and sleep · 2025Review
- Intrinsic Skeletal Muscle Function and Contraction-Stimulated Glucose Uptake Do Not Vary by Time-of-Day in Mice.Function (Oxford, England) · 2024Article
- Dopamine Switches Affective States Under Acute Sleep Deprivation.Neuroscience bulletin · 2024Article
- Hidden variables in stress neurobiology research.Trends in neurosciences · 2024Review
- Review
- REV-ERBα Agonist SR9009 Promotes a Negative Energy Balance in Goldfish.International journal of molecular sciences · 2022Article
- The Mind After Midnight: Nocturnal Wakefulness, Behavioral Dysregulation, and Psychopathology.Frontiers in network physiology · 2022Article
- Targeting Histamine and Histamine Receptors for the Precise Regulation of Feeding.Current topics in behavioral neurosciences · 2022Review
- The Ventral Tegmental Area and Nucleus Accumbens as Circadian Oscillators: Implications for Drug Abuse and Substance Use Disorders.Frontiers in physiology · 2022Review
- Dopamine systems and biological rhythms: Let's get a move on.Frontiers in integrative neuroscience · 2022Review
- Snack timing affects tissue clock and metabolic responses in male mice.Frontiers in nutrition · 2022Article
- Non-alcoholic fatty liver disease (NAFLD) and mental illness: Mechanisms linking mood, metabolism and medicines.Frontiers in neuroscience · 2022Review
- Racing and Pacing in the Reward System: A Multi-Clock Circadian Control Over Dopaminergic Signalling.Frontiers in physiology · 2022Article
- Association between Irregular Meal Timing and the Mental Health of Japanese Workers.Nutrients · 2021Article
- Feto-Maternal Crosstalk in the Development of the Circadian Clock System.Frontiers in neuroscience · 2020Review
Corrections and comments
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Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Unlimited access to calorie-dense, palatable food is a hallmark of Western societies and substantially contributes to the worldwide rise of metabolic disorders. In addition to promoting overconsumption, palatable diets dampen daily intake patterns, further augmenting metabolic disruption. We developed a paradigm to reveal differential timing in the regulation of food intake behavior in mice. While homeostatic intake peaks in the active phase, conditioned place preference and choice experiments show an increased sensitivity to overeating on palatable food during the rest phase. This hedonic appetite rhythm is driven by endogenous circadian clocks in dopaminergic neurons of the ventral tegmental area (VTA). Mice with disrupted clock function in the VTA lose their hedonic overconsumption rhythms without affecting homeostatic intake. These findings assign a functional role of VTA clocks in modulating palatable feeding behaviors and identify a potential therapeutic route to counteract hyperphagy in an obesogenic environment.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.