ArticleNature communications2020
The phytopathogenic fungus Sclerotinia sclerotiorum detoxifies plant glucosinolate hydrolysis products via an isothiocyanate hydrolase.
Article in Nature communications, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers, 1 of them a synthesis that pooled it.
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Who cites it
49 citing papers in PubMed, 1 synthesis or guideline pooled it, 112 citations in OpenAlex.
- Tryptophan metabolism and plant health: mechanisms of action and application prospects.Frontiers in plant science · 2026Pooled it
- Bacterial degradation of a plant toxin and nutrient competition with commensals trade off to constrain pathogen growth.mSystems · 2026Article
- Metabolomic analysis of a core collection of Brassica rapa and Brassica oleracea unveils unexpected chemical diversity with potential applications in chemical ecology and breeding.BMC plant biology · 2026Article
- High-Resolution LC-MS Characterization ofToxins · 2026Article
- A Guide to Culturing, Maintenance, and Leaf Inoculation Methods for Rapid Screening and Quantification of Sclerotinia sclerotiorum Infection in Mustard.Methods in molecular biology (Clifton, N.J.) · 2026Article
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- Towards Understanding the Factors Shaping the Composition and Function of theInternational journal of molecular sciences · 2025Review
- Beyond defense: microbial modifications of plant specialized metabolites alter and expand their ecological functions.The New phytologist · 2025Review
- Isoamyl isothiocyanate preserves postharvest quality of matsutake (Frontiers in plant science · 2025Article
- Comparative insights into soybean and other oilseed crops' defense mechanisms againstFrontiers in plant science · 2025Review
- Glucosinolate structural diversity shapes recruitment of a metabolic network of leaf-associated bacteria.Nature communications · 2024Article
- Integrative Analyses of Metabolites and Transcriptome Reveal the Metabolic Pattern of Glucosinolates in Potherb Mustard (Plants (Basel, Switzerland) · 2024Article
- Comparative analysis of infected cassava root transcriptomics reveals candidate genes for root rot disease resistance.Scientific reports · 2024Article
- Comparing Fungal Sensitivity to Isothiocyanate Products on DifferentPlants (Basel, Switzerland) · 2024Article
- Gregarines impact consumption and development but not glucosinolate metabolism in the mustard leaf beetle.Frontiers in physiology · 2024Article
- Recent advances in virulence of a broad host range plant pathogenFrontiers in microbiology · 2024Review
- An atypical heterotrimeric Gα and its interactome suggest an extra-large role in overcoming abiotic and biotic stress.Physiology and molecular biology of plants : an international journal of functional plant biology · 2023Review
- Metabolism of plant-derived toxins from its insect host increases the success of the entomopathogenic fungus Beauveria bassiana.The ISME journal · 2023Article
- Spectral Reflectance Indexes Reveal Differences in the Physiological Status ofPlants (Basel, Switzerland) · 2023Article
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Brassicales plants produce glucosinolates and myrosinases that generate toxic isothiocyanates conferring broad resistance against pathogens and herbivorous insects. Nevertheless, some cosmopolitan fungal pathogens, such as the necrotrophic white mold Sclerotinia sclerotiorum, are able to infect many plant hosts including glucosinolate producers. Here, we show that S. sclerotiorum infection activates the glucosinolate-myrosinase system, and isothiocyanates contribute to resistance against this fungus. S. sclerotiorum metabolizes isothiocyanates via two independent pathways: conjugation to glutathione and, more effectively, hydrolysis to amines. The latter pathway features an isothiocyanate hydrolase that is homologous to a previously characterized bacterial enzyme, and converts isothiocyanate into products that are not toxic to the fungus. The isothiocyanate hydrolase promotes fungal growth in the presence of the toxins, and contributes to the virulence of S. sclerotiorum on glucosinolate-producing plants.
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