ArticleNature communications2020
Evolution of generalist resistance to herbicide mixtures reveals a trade-off in resistance management.
Article in Nature communications, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 46 papers.
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Who cites it
46 citing papers in PubMed.
- Digitaria genome analyses indicate introgression may drive local adaptation and herbicide resistance.Nature communications · 2026Article
- Extrachromosomal circular DNA are functional, heritable units that expand genomic plasticity and confer resilience.Frontiers in plant science · 2026Review
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- Distribution patterns and community assembly processes of generalists and specialists in river affected by wastewater discharge from distilleries in typical Chinese spirits production area in China.Frontiers in microbiology · 2026Article
- The genetic architecture and spatiotemporal dynamics of adaptation across human-modified landscapes.The New phytologist · 2026Review
- Blackgrass (Genes · 2025Article
- Fabricating supramolecular pre-emergence herbicide CPAM-BPyHs for farming herbicide-resistant rice.Nature communications · 2025Article
- Crop diversity induces trade-offs in microbial biopesticide susceptibility that could delay pest resistance evolution.PLoS pathogens · 2025Article
- Article
- RNAi spray-induced gene silencing ofFrontiers in plant science · 2025Article
- Chromosome-scale genome assembly and de novo annotation of Alopecurus aequalis.Scientific data · 2024Article
- Protorhabditis nematodes and pathogen-antagonistic bacteria interactively promote plant health.Microbiome · 2024Article
- Epiphytic Fungi Can Drive a Trade-Off Between Pathogen and Herbivore Resistance in InvasiveMicroorganisms · 2024Article
- Current status of community resources and priorities for weed genomics research.Genome biology · 2024Review
- Multifunctional Adjuvants Affect Sulfonylureas with Synthetic Auxin Mixture in Weed and Maize Grain Yield.Plants (Basel, Switzerland) · 2024Article
- Incidence of resistance to ALS and ACCase inhibitors in Echinochloa species and soil microbial composition in Northern Italy.Scientific reports · 2024Article
- Trade-offs constrain the success of glyphosate-free farming.Scientific reports · 2024Article
- Genetic Mechanism of Non-Targeted-Site Resistance to Diquat inPlants (Basel, Switzerland) · 2024Article
- Trp-574-Leu and the novel Pro-197-His/Leu mutations contribute to penoxsulam resistance inFrontiers in plant science · 2024Article
- Repeated evolution of herbicide resistance inEvolutionary applications · 2023Article
Corrections and comments
- Erratum issued
Authors and funding
11 authors.
Funding
Abstract
Intense selection by pesticides and antibiotics has resulted in a global epidemic of evolved resistance. In agriculture and medicine, using mixtures of compounds from different classes is widely accepted as optimal resistance management. However, this strategy may promote the evolution of more generalist resistance mechanisms. Here we test this hypothesis at a national scale in an economically important agricultural weed: blackgrass (Alopecurus myosuroides), for which herbicide resistance is a major economic issue. Our results reveal that greater use of herbicide mixtures is associated with lower levels of specialist resistance mechanisms, but higher levels of a generalist mechanism implicated in enhanced metabolism of herbicides with diverse modes of action. Our results indicate a potential evolutionary trade-off in resistance management, whereby attempts to reduce selection for specialist resistance traits may promote the evolution of generalist resistance. We contend that where specialist and generalist resistance mechanisms co-occur, similar trade-offs will be evident, calling into question the ubiquity of resistance management based on mixtures and combination therapies.
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