ArticleTranslational psychiatry2020
Using polygenic scores for identifying individuals at increased risk of substance use disorders in clinical and population samples.
Article in Translational psychiatry, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
39 citing papers in PubMed, 2 syntheses or guidelines pooled it, 59 citations in OpenAlex.
- Genomic risk for post-traumatic stress disorder in families densely affected with alcohol use disorders.Molecular psychiatry · 2023Pooled it
- Fully exploiting SNP arrays: a systematic review on the tools to extract underlying genomic structure.Briefings in bioinformatics · 2022Pooled it
- Polygenic risk for alcohol consumption and multisite chronic pain: Associations with ad lib drinking behavior.Experimental and clinical psychopharmacology · 2023Trial
- The Contributions of Multiple Polygenic Scores in Predicting Liability for Major Depressive Disorder and Its Comorbidity with Alcohol Use Disorder.Behavior genetics · 2026Article
- Polygenic risk moderation of stressful life events in alcohol use disorder severity.BMC psychiatry · 2026Article
- The Promise of Genetics in Alcohol Use Disorders and the Problems of Phenotype, Polygenetic Architecture, Ancestry, and Comorbidity.The American journal of psychiatry · 2025Article
- Post-traumatic stress and genetic interactions affect tobacco and alcohol use after trauma: findings from a multi-ancestry cohort.Translational psychiatry · 2025Article
- Predicting treatment-seeking status for alcohol use disorder using polygenic scores and machine learning in a deeply-phenotyped sample.Drug and alcohol dependence · 2025Article
- The impact of the COVID-19 pandemic on alcohol use disorder symptoms: Testing interactions with polygenic risk.Journal of American college health : J of ACH · 2025Article
- Principles and Policy Recommendations for Comprehensive Genetic Data Governance.Proceedings of the AAAI/ACM Conference on AI, Ethics, and Society · 2025Article
- Article
- Polygenic risk for alcohol use disorder affects cellular responses to ethanol exposure in a human microglial cell model.Science advances · 2024Article
- Associations between alcohol use disorder polygenic score and remission in participants from high-risk families and the Indiana Biobank.Alcohol, clinical & experimental research · 2024Article
- Correlates of Risk for Disinhibited Behaviors in the Million Veteran Program Cohort.JAMA psychiatry · 2024Article
- Positive personality traits moderate persistent high alcohol consumption, determined by polygenic risk in U.S. military veterans: results from a 10-year, population-based, observational cohort study.Psychological medicine · 2023Observational
- Alcohol use polygenic risk score, social support, and alcohol use among European American and African American adults.Development and psychopathology · 2023Article
- 5. Collaborative Study on the Genetics of Alcoholism: Functional genomics.Genes, brain, and behavior · 2023Review
- The collaborative study on the genetics of alcoholism: Sample and clinical data.Genes, brain, and behavior · 2023Review
- Polygenic risk scores point toward potential genetic mechanisms of type 2 myocardial infarction in people with HIV.International journal of cardiology · 2023Article
- Correlates of Risk for Disinhibited Behaviors in the Million Veteran Program Cohort.medRxiv : the preprint server for health sciences · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
19 authors at 11 institutions in 3 countries.
Funding
Abstract
Genome-wide, polygenic risk scores (PRS) have emerged as a useful way to characterize genetic liability. There is growing evidence that PRS may prove useful for early identification of those at increased risk for certain diseases. The current potential of PRS for alcohol use disorders (AUD) remains an open question. Using data from both a population-based sample [the FinnTwin12 (FT12) study] and a high-risk sample [the Collaborative Study on the Genetics of Alcoholism (COGA)], we examined the association between PRSs derived from genome-wide association studies (GWASs) of (1) alcohol dependence/alcohol problems, (2) alcohol consumption, and (3) risky behaviors with AUD and other substance use disorder (SUD) criteria. These PRSs explain ~2.5-3.5% of the variance in AUD (across FT12 and COGA) when all PRSs are included in the same model. Calculations of area under the curve (AUC) show PRS provide only a slight improvement over a model with age, sex, and ancestral principal components as covariates. While individuals in the top 20, 10, and 5% of the PRS distribution had greater odds of having an AUD compared to the lower end of the continuum in both COGA and FT12, the point estimates at each threshold were statistically indistinguishable. Those in the top 5% reported greater levels of licit (alcohol and nicotine) and illicit (cannabis and opioid) SUD criteria. PRSs are associated with risk for SUD in independent samples. However, usefulness for identifying those at increased risk in their current form is modest, at best. Improvement in predictive ability will likely be dependent on increasing the size of well-phenotyped discovery samples.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.