Evidence map›Paper›PMID 32555070›Full record

Trial reportJournal of developmental and behavioral pediatrics : JDBP

Subtle Motor Signs as a Biomarker for Mindful Movement Intervention in Children with Attention-Deficit/Hyperactivity Disorder.

Dav Clark, Karen E Seymour, Robert L Findling, Stewart H Mostofsky

Registry-linked trialOpen access · greenAbstract readClinical Trial
In one paragraph

Trial report in Journal of developmental and behavioral pediatrics : JDBP. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02234557 (Movement-Based Training for Children With ADHD), which is not on this map. Cited by 6 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 2 pooled it
0.9field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02234557 nacompletednot on this map

Movement-Based Training for Children With ADHD: A Feasibility Study

TypeinterventionalSponsorHugo W. Moser Research Institute at Kennedy Krieger, Inc.Ran2014 to 2020Enrolled59ConditionsADHDArmsTai Chi
3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 2 syntheses or guidelines pooled it, 14 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Review
  4. Article
  5. Inter-rater Reliability of the Revised Physical and Neurological Examination of Subtle Signs (PANESS) scored using video review.Child neuropsychology : a journal on normal and abnormal development in childhood and adolescence · 2023
    Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Dav ClarkKennedy Krieger Institute, Center for Neurodevelopmental and Imaging Research, Baltimore, MD. Dr. Clark is now working at Gigantum, Washington, DC.
Karen E SeymourKennedy Krieger Institute, Center for Neurodevelopmental and Imaging Research, Baltimore, MD. Dr. Clark is now working at Gigantum, Washington, DC.
Robert L FindlingDepartment of Psychiatry, Johns Hopkins University School of Medicine, Baltimore, MD.
Stewart H MostofskyKennedy Krieger Institute, Center for Neurodevelopmental and Imaging Research, Baltimore, MD. Dr. Clark is now working at Gigantum, Washington, DC.
Kennedy Krieger Institute · USJohns Hopkins Medicine · US

Funding

Anomalous Motor Physiology In ADHDR01MH078160 · NIMH · HUGO W. MOSER RES INST KENNEDY KRIEGER · PI MOSTOFSKY, STEWART H · 2006 to 2024
$5.8M
Neurobehavioral Correlates of Frustration in Children with ADHDK23MH107734 · NIMH · JOHNS HOPKINS UNIVERSITY · PI SEYMOUR, KAREN E · 2015 to 2019
$815k
Movement-Based Training for Children with ADHD: A Feasibility StudyR21MH104651 · NIMH · HUGO W. MOSER RES INST KENNEDY KRIEGER · PI MOSTOFSKY, STEWART H · 2014 to 2015
$519k
NIMH NIH HHS K23 MH107734NIMH NIH HHS R01 MH078160NIMH NIH HHS R21 MH104651
6 · The paper itself

Abstract

objectivePrevious studies of Tai Chi or mindfulness-based interventions in attention-deficit/hyperactivity disorder (ADHD) have relied on self- or parent-reported outcome measures; however, there is a critical need for the validation of objective biomarkers of treatment. Therefore, we implemented a mindful movement intervention for children with ADHD, hypothesizing that an ADHD-relevant motor control measure could serve as a predictive biomarker of treatment-related improvement.

methodsThirty-four participants were included, 8 to 12 year olds diagnosed with DSM-5 ADHD. Participants engaged in the mindful movement treatment, an 8-week program with 2 classes a week for 60 minutes. At pre- and post-treatment, ADHD symptoms and associated impairment and motor control via the Physical and Neurological Examination for Subtle Signs (PANESS) were assessed.

resultsThe results showed a significant reduction for PANESS Gaits and Station (p ≤ 0.001), total overflow (p = 0.009), and total score (p = 0.001) after treatment, with the largest effect for Gaits and Stations. The results also showed a significant reduction in symptoms of inattention (p ≤ 0.001), hyperactivity/impulsivity (p ≤ 0.001), oppositional defiant disorder (p = 0.001), and executive dysfunction (p ≤ 0.001). There were significant positive correlations between change in PANESS Gaits and Stations and change in both inattentive (p = 0.02) and hyperactive/impulsive symptoms (p = 0.02). There was also a significant positive correlation between change in the PANESS total score and change in inattentive (p = 0.007) and hyperactive/impulsive symptoms (p = 0.042). The change in the PANESS total score (β = 0.295, p = 0.002) predicted post-treatment ADHD severity above the change in inattentive or hyperactive/impulsive symptoms.

conclusionThe results suggest the effectiveness of a mindful movement treatment on ADHD symptoms and suggest the PANESS as a candidate motor biomarker for future mindful movement trials. CLINICAL

trial registrationClinicalTrials.gov, NCT02234557, https://clinicaltrials.gov/ct2/show/NCT02234557.

Indexed as

Exercise Movement TechniquesMindfulnessOutcome Assessment, Health CareAttention Deficit Disorder with HyperactivityBiomarkersChildFemaleHumansMalePostural BalanceSeverity of Illness IndexWalkingBiomarkers

Identifiers

PMID32555070
PMCPMC7554196
OpenAlexW3016273728

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.