Evidence map›Paper›PMID 32555010›Full record

ReviewNursing research

Integrative Review of Gut Microbiota and Expression of Symptoms Associated With Neonatal Abstinence Syndrome.

Stephanie D Sealschott, Rita H Pickler, Christine A Fortney, Michael T Bailey

Open access · greenAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Nursing research. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.7field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 2 countries.

Stephanie D SealschottStephanie D. Sealschott, MS, RN, is PhD Candidate, College of Nursing, The Ohio State University, Columbus. Rita H. Pickler, PhD, RN, FAAN, is FloAnn Sours Easton Professor of Child and Adolescent Health, College of Nursing, The Ohio State University, Columbus. Christine A. Fortney, PhD, RN, is Assistant Professor, College of Nursing, The Ohio State University, Columbus. Michael T. Bailey, PhD, is Associate Professor of Pediatrics, The Ohio State University, and Principle Investigator, Center for Microbial Pathogenesis, Abigail Wexner Research Institute, Nationwide Children's Hospital, Columbus, Ohio.
Rita H Pickler
Christine A Fortney
Michael T Bailey
Apple (Israel) · IL

Funding

Training in the Science of Health DevelopmentT32NR014225 · NINR · OHIO STATE UNIVERSITY · PI MARY E HAPP, Rita H Pickler · 2013 to 2026
$2.6M
NINR NIH HHS T32 NR014225
6 · The paper itself

Abstract

backgroundNeonatal exposure and subsequent withdrawal from maternal substance use disorder are a growing problem and consequence of the current opioid epidemic. Neonatal abstinence syndrome (NAS) is defined by a specified cluster of symptoms with treatment guided by the expression and severity of these symptoms. The mechanisms or pathophysiology contributing to the development of NAS symptoms are not well known, but one factor that may influence NAS symptoms is the gut microbiota.

objectivesThe purpose of this integrative review was to examine evidence that might show if and how the gut microbiota influence expression and severity of symptoms similar to those seen in NAS.

methodsUsing published guidelines, a review of research studies that focused on the gut microbiome and symptoms similar to those seen in NAS was conducted, using the Cochrane, EMBASE, and Scopus databases, from 2009 through 2019.

resultsThe review results included findings of aberrant microbial diversity, differences in microbial communities between study groups, and associations between specific taxa and symptoms. In studies involving interventions, there were reports of improved microbial diversity, community structure, and symptoms. DISCUSSION: The review findings provide evidence that the gut microbiota may play a role in modifying variability in the expression and severity of symptoms associated with NAS. Future research should focus on examining the gut microbiota in infants with and without the syndrome as well as exploring the relationship between symptom expression and aberrant gut microbiota colonization in infants with NAS.

Indexed as

SyndromeCorrelation of DataFemaleGastrointestinal MicrobiomeHumansInfant, NewbornNeonatal Abstinence SyndromeOpiate Substitution TreatmentPregnancyPregnancy Complications

Identifiers

PMID32555010
PMCPMC7483611
OpenAlexW3035847429

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.