Evidence map›Paper›PMID 32555009›Full record

ReviewNursing research

An Integrative Review of Brain-Derived Neurotrophic Factor and Serious Cardiovascular Conditions.

Shannon Halloway, Miyeon Jung, An-Yun Yeh, Jia Liu, Ellen McAdams, Maddison Barley, Susan G Dorsey, Susan J Pressler

Registry-linked trialOpen access · greenAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Nursing research. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03035565 (Cognitive Intervention to Improve Memory in Heart Failure Patients), which is not on this map. Cited by 18 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed, 2 pooled it
2.2field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03035565 nacompletednot on this map

Cognitive Intervention to Improve Memory in Heart Failure Patients

TypeinterventionalSponsorIndiana UniversityRan2017 to 2021Enrolled276ConditionsHeart Failure NYHA Class II, Heart Failure NYHA Class III, Heart Failure NYHA Class IArmsComputerized Cognitive Training with Brain HQ, Computerized Crossword Puzzles
3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 2 syntheses or guidelines pooled it, 31 citations in OpenAlex.

  1. Pooled it
  2. Exergames in Childhood Obesity Treatment: A Systematic Review.International journal of environmental research and public health · 2021
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Shannon HallowayShannon Halloway, PhD, RN, is Assistant Professor, College of Nursing, Rush University, Chicago, Illinois. Miyeon Jung, PhD, RN, is Assistant Professor, School of Nursing, Indiana University, Indianapolis. An-Yun Yeh, PhD, RN, is Assistant Professor, Hunter-Bellevue School of Nursing, New York, New York. Jia Liu, PhD, RN, is Visiting Research Associate, School of Nursing, Indiana University, Indianapolis Ellen McAdams, BSW, Student, Indiana University-Purdue University Indianapolis. She is now an Industrial/Organizational Psychology Student, East Carolina University Department of Psychology, Greenville, North Carolina. Maddison Barley, is Nursing Student, Indiana University-Purdue University Indianapolis. Susan G. Dorsey, PhD, RN, FAAN, is Professor and Chair, Department of Pain and Translational Symptom Science, School of Nursing, University of Maryland, Baltimore. Susan J. Pressler, PhD, RN, FAAN, FAHA, is Professor, Sally Reahard Chair, and the Director of the Center for Enhancing Quality of Life in Chronic Illness, School of Nursing, Indiana University, Indianapolis.
Miyeon Jung
An-Yun Yeh
Jia Liu
Ellen McAdams
Maddison Barley
Susan G Dorsey
Susan J Pressler
Indiana University – Purdue University Indianapolis · USUniversity of Maryland, Baltimore · US

Funding

Cognitive Intervention to Improve Memory in Heart Failure PatientsR01NR016116 · NINR · INDIANA UNIVERSITY INDIANAPOLIS · PI GIORDANI, BRUNO, PRESSLER, SUSAN JANE · 2016 to 2020
$2.9M
NINR NIH HHS R01 NR016116
6 · The paper itself

Abstract

backgroundThere is emerging evidence that supports a role for brain-derived neurotrophic factor (BDNF) in the risk and presence of serious cardiovascular conditions. However, few existing literature reviews methodically describe empirical findings regarding this relationship.

objectivesThe purpose of this integrative review was to (a) evaluate BDNF (serum/plasma BDNF levels, BDNF Val66Met genotype) among humans at risk for or with serious cardiovascular conditions and (b) investigate the relationship between BDNF and risk/presence of serious cardiovascular conditions in humans.

methodsAn integrative review was conducted. Articles in English included human subjects, a measure of BDNF levels or BDNF gene, serious cardiovascular conditions, and quantitative data analyses. The search resulted in 475 unique titles, with the final sample including 35 articles representing 30 studies. Articles that received "good" or "fair" ratings (n = 31) using the National Heart, Lung, and Blood Institute Study Quality Assessment Tools were included for synthesis.

resultsThe retrieved articles were largely nonexperimental, with sample sizes ranging from 20 to 5,510 participants. Overall, BDNF levels were lower in patients with chronic heart failure and stroke, but higher in patients with unstable angina and recent myocardial infarction. Lower BDNF levels were associated with higher incidence of cardiovascular events in patients with a prior history of serious cardiovascular conditions and decreased cardiovascular risk in healthy samples. For BDNF genotype, on average, 36.3% of participants had Met alleles. The frequency of the BDNF Met allele varied across race/ethnicity and cardiovascular conditions and in terms of association with serious cardiovascular condition incidence/risk. DISCUSSION: These findings indicate an emerging area of science. Future investigation is needed on serious cardiovascular condition phenotypes in relationship to BDNF in the same study conditions. Results also suggest for use of standardized BDNF measurement across studies and additional investigation in cardiovascular inflammatory processes that affect BDNF. Moreover, within specific populations, the frequency of Met alleles may be too low to be detected in sample sizes normally found in these types of studies.

Indexed as

BiomarkersBrain-Derived Neurotrophic FactorCardiovascular DiseasesCritical IllnessGenotypeHumansBiomarkersBrain-Derived Neurotrophic Factor

Identifiers

PMID32555009
PMCPMC11448954
OpenAlexW3036664867

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.